CONTROL OF COVULSIVE STATUS EPILEPTICUS BY INTRAVENOUS IMMUNOGLOBULIN IN CHILDREN

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MOAYEDI A.R.

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Journal: Hormozgan Medical Journal Year:2003 | Volume:6 | Issue:4 Page(s): 9-14

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Title

CONTROL OF COVULSIVE STATUS EPILEPTICUS BY INTRAVENOUS IMMUNOGLOBULIN IN CHILDREN

Author(s)

MOAYEDI A.R. | Issue Writer Certificate

Keywords

EPILEPSYQ3

ANTICONVULSANTSQ3

IMMUNOGLOBULINSQ3

INTRAVENOUSQ4

CHILDQ2

Abstract

Introduction: EPILEPSY is one of the major problems of pediatric medicine. According to world statistics 5-8 CHILDren out of 1000 have been reported having EPILEPSY.On the other hand about 20%-30% of epilepsies are unresponsive to anticonvulsant drugs. Therefore, broad investigations are made all over the world to find an appropriate anticonvulsant treatment. One of the newest treatments for status epilepticus is INTRAVENOUS immunoglobulin (IVIG). This investigation has been conducted to assess the efficacy of IVIG for controlling convulsive epilepticus in CHILDren. Method & Material: This case-control study was performed on 17 pediatric patients as cases from 21 April 1998. Seizure frequency of all patients consisting of 13 boys and 8 girls was recorded 8 weeks prior to the administration of IVIG. Then each patient received 15 INTRAVENOUS immunoglobulin in a seven-week period. 8 weeks after the last IVIG administration seizure frequency was observed as control group and compared to that of the original one. Data analysis was performed using paired t-test and wilcoxon signed-rank test and p<0.05 was considered as significant. Results: Paired t-test showed a significant reduction in seizure frequency after and before the last administration of IVIG (p<0.05) and wilcoxon test showed a decrease of seizure frequency after and before treatment too (p<0.05). All patients had received anticonvulsant drugs and 13 of them also had been placed on ketogenic which were not successful in controlling seizures. In 3 CHILDren out of 17, seizure was stopped. In 7 CHILDren the decrease in seizure frequency was 50% and in 10 CHILDren an improvement was observed in general condition compared to that of prior to IVIG administration. Conclusion: Since IVIG has shown to be effective for controlling some types of EPILEPSY like LGS and infantile spasms, it is recommended for controlling status epilepticus if other types of treatments fail to control it.

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APA: Copy

MOAYEDI, A.R.. (2003). CONTROL OF COVULSIVE STATUS EPILEPTICUS BY INTRAVENOUS IMMUNOGLOBULIN IN CHILDREN. HORMOZGAN MEDICAL JOURNAL, 6(4), 9-14. SID. https://sid.ir/paper/60563/en

Vancouver: Copy

MOAYEDI A.R.. CONTROL OF COVULSIVE STATUS EPILEPTICUS BY INTRAVENOUS IMMUNOGLOBULIN IN CHILDREN. HORMOZGAN MEDICAL JOURNAL[Internet]. 2003;6(4):9-14. Available from: https://sid.ir/paper/60563/en

IEEE: Copy

A.R. MOAYEDI, “CONTROL OF COVULSIVE STATUS EPILEPTICUS BY INTRAVENOUS IMMUNOGLOBULIN IN CHILDREN,” HORMOZGAN MEDICAL JOURNAL, vol. 6, no. 4, pp. 9–14, 2003, [Online]. Available: https://sid.ir/paper/60563/en

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