EFFICACY OF 0.05% TOPICAL SOLUTION OF TRETINOIN ON HEALING OF CHRONIC ULCERS AND COMPARISON OF IT WITH 1% TOPICAL CREAM OF PHENYTOIN

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LAYEGH POURAN; YAZDANPANAH MOHAMMAD JAVAD; AMOUZGAR M.H.; SARRAF F.

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Journal: MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES Year:2005 | Volume:48 | Issue:89 Page(s): 321-328

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Title

EFFICACY OF 0.05% TOPICAL SOLUTION OF TRETINOIN ON HEALING OF CHRONIC ULCERS AND COMPARISON OF IT WITH 1% TOPICAL CREAM OF PHENYTOIN

Author(s)

LAYEGH POURAN | YAZDANPANAH MOHAMMAD JAVAD | AMOUZGAR M.H. | SARRAF F. | Issue Writer Certificate

Keywords

TRETINOIN SOLUTIONQ4

PHENYTOIN CREAMQ4

CHRONIC ULCERQ4

Abstract

Introduction: CHRONIC ULCER with any kind of etiology is one of the therapeutic problems for patients and medical services. With respect to appropriate effects of retinoids on different stages of wound healing, we decided to evaluate efficacy of 0.05% topical solution of tretinoin on topical treatment of ulcers in comparison with 1% topical cream of phenytoin ,that its effects on wound healing has been approved in several studies.Material and method: In an interventional, clinical trial topical effect of these two drugs on healing of CHRONIC ULCERs of 30 patients with 37 ulcers was compared. with random allocation patients divided to two groups and finally 15 patients with 18 ulcers treated with 1% topical cream of phenytoin and 15 patients with 19 ulcers treated with 0.05% topical solution of tretinoin. Then followed up for 6 weeks and evaluated for criteria of clinical recovery (size, depth, secretion and pain) in weekly visits. Analytic tests were done by using the chi-square test and P<0.05 was accepted as significant.Results: At the end of, the treatment in phenytoin group 42.6±44.9% and in tretinoin group 44.71±43.4% of ulcers width were reduced. Also at this time ulcers' depth were diminished whereas in phenytoin group 55.6% and in tretinoin group 26.3% of those were in superficial dermis. Before treatment in phenytoin group 55.6% of ulcers were without pain though after it 100% of them had no pain. In tretinoin group ulcers without pain increased from 78.9% before to 84.2% after treatment. Percentage of ulcers with no secretion increased from 33.3% to 55.6% in phenytoin group and from 26.3% to 68.4% in tretinoin group.Conclusion: With respect to results, TRETINOIN SOLUTION as PHENYTOIN CREAM can be used as an appropriate topical treatment for CHRONIC ULCER.

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APA: Copy

LAYEGH, POURAN, YAZDANPANAH, MOHAMMAD JAVAD, AMOUZGAR, M.H., & SARRAF, F.. (2005). EFFICACY OF 0.05% TOPICAL SOLUTION OF TRETINOIN ON HEALING OF CHRONIC ULCERS AND COMPARISON OF IT WITH 1% TOPICAL CREAM OF PHENYTOIN. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 48(89), 321-328. SID. https://sid.ir/paper/51722/en

Vancouver: Copy

LAYEGH POURAN, YAZDANPANAH MOHAMMAD JAVAD, AMOUZGAR M.H., SARRAF F.. EFFICACY OF 0.05% TOPICAL SOLUTION OF TRETINOIN ON HEALING OF CHRONIC ULCERS AND COMPARISON OF IT WITH 1% TOPICAL CREAM OF PHENYTOIN. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2005;48(89):321-328. Available from: https://sid.ir/paper/51722/en

IEEE: Copy

POURAN LAYEGH, MOHAMMAD JAVAD YAZDANPANAH, M.H. AMOUZGAR, and F. SARRAF, “EFFICACY OF 0.05% TOPICAL SOLUTION OF TRETINOIN ON HEALING OF CHRONIC ULCERS AND COMPARISON OF IT WITH 1% TOPICAL CREAM OF PHENYTOIN,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 48, no. 89, pp. 321–328, 2005, [Online]. Available: https://sid.ir/paper/51722/en

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