COMPARISON OF EFFICACY OF TOPICAL TRETINOIN 0.05% CREAM WITH PLACEBO IN TREATMENT OF MELASMA

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SHOHRATI M.; HOSSEINI S.M.J.; SAEID FAR H.R.; TAJIK A.; SEYRAFI H.; NAGHIZADEH JAHROMI M.M.

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Journal: Annals of Military and Health Sciences Research Year:2005 | Volume:3 | Issue:4 (SERIAL NUMBER 12) Page(s): 673-678

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Title

COMPARISON OF EFFICACY OF TOPICAL TRETINOIN 0.05% CREAM WITH PLACEBO IN TREATMENT OF MELASMA

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Keywords

MELASMAQ4

TOPICAL CREAMQ4

TRETINIONQ4

Abstract

Background: MELASMA is a common disorder of macular hyperpigmentation, which involves mostly in sun- exposed areas of face and neck. Women are more affected. Multiple factors have been postulated to involve in the etiology and pathogenesis of MELASMA including pregnancy, oral contraceptives, genetics, sun exposure, cosmetics and race.Materials and methods: Fifty women completed a randomized, double blind vehicle controlled clinical trial, in which they applied 0.05%tretinoin (n=25) or vehicle cream (n=25) once daily on the face for 12weeks.Results: 2 weeks after treatment 6 out of 25(24%) tretinoin- treated patients (group 1) were clinically improved, compared with 0 out of 25(0%) in the vehicle group (group2)(p=0.022). 4 weeks after treatment 14(56%)of group1 and 5(20%) of group2 improved(p=0.006).After 12weeks, 21(84%) of group1 and 6(24%) of group2 were improved(p=0.0001) which demonstrated significant improvement in the tretinoin- treated patients compared with the vehicle group.Conclusions: This controlled study demonstrates that topical 0.05% tretinoin alone is considered to be effective in the treatment of MELASMA patients.

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APA: Copy

SHOHRATI, M., HOSSEINI, S.M.J., SAEID FAR, H.R., TAJIK, A., SEYRAFI, H., & NAGHIZADEH JAHROMI, M.M.. (2005). COMPARISON OF EFFICACY OF TOPICAL TRETINOIN 0.05% CREAM WITH PLACEBO IN TREATMENT OF MELASMA. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, 3(4 (SERIAL NUMBER 12)), 673-678. SID. https://sid.ir/paper/96742/en

Vancouver: Copy

SHOHRATI M., HOSSEINI S.M.J., SAEID FAR H.R., TAJIK A., SEYRAFI H., NAGHIZADEH JAHROMI M.M.. COMPARISON OF EFFICACY OF TOPICAL TRETINOIN 0.05% CREAM WITH PLACEBO IN TREATMENT OF MELASMA. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH[Internet]. 2005;3(4 (SERIAL NUMBER 12)):673-678. Available from: https://sid.ir/paper/96742/en

IEEE: Copy

M. SHOHRATI, S.M.J. HOSSEINI, H.R. SAEID FAR, A. TAJIK, H. SEYRAFI, and M.M. NAGHIZADEH JAHROMI, “COMPARISON OF EFFICACY OF TOPICAL TRETINOIN 0.05% CREAM WITH PLACEBO IN TREATMENT OF MELASMA,” ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, vol. 3, no. 4 (SERIAL NUMBER 12), pp. 673–678, 2005, [Online]. Available: https://sid.ir/paper/96742/en

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