A STUDY OF DIAGNOSTIC & PREDICTIVE VALUE OF SERUM SOLUBLE INTERLEUKIN-2 RECEPTOR A (SIL-2A) ON ACUTE REJECTION OF RENAL TRANSPLANTATION

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NAGHIBI M.; HASAN NIYA T.; MOJAHEDI M.J.; REZAEEI A.; BEHROZ AGHDAM A.; FARID HOSSINI R.

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Journal: Medical Journal of Mashhad University of Medical Sciences Year:2001 | Volume:44 | Issue:72 Page(s): 21-27

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Title

A STUDY OF DIAGNOSTIC & PREDICTIVE VALUE OF SERUM SOLUBLE INTERLEUKIN-2 RECEPTOR A (SIL-2A) ON ACUTE REJECTION OF RENAL TRANSPLANTATION

Author(s)

Keywords

RENAL TRANSPLANTATIONQ3

ACUTE REJECTIONQ4

ALLOGRAFT REJECTIONQ4

IL-2RQ4

SIL-2RA AND REJECTIONQ4

Abstract

The diagnosis and prediction of acute ALLOGRAFT REJECTION as well as differentiation of rejection crisis from other renal dysfunction have the most important role in renal transplant follow up.IL-2Ra is a member of the IL-2R that appears up on T cell activation in immune responses. As in general, cell-mediated immune reactions are more important for rejection of transplanted organs, most studies to tissue transplants have focused on T cell responses (esp on IL-2 and IL-2Ranetwork). For monitoring of renal transplant, serum I 1-2Ra (SIL-2Ra) was evaluated in 30 recipients and 20 healthy subjects. According to clinical diagnosis the patients were in two groups (successful renal transplant and ACUTE REJECTION). The mean concentration of s1L-2Ra was 273 Pg/m I in control group. In the other hand, the mean concentration of s1L-2Ra pretransplantation was 940 Pg/m I in control goup. In the other hand, the mean concentration of sIl-2Ra pretransplantation was 940 Pg/ml in successful renal transplant and 1116 in ACUTE REJECTION group which had a meaningful difference with control subjects (P<0.0001).Before transplantation no significant difference in s1L-2Ra was observed between two transplant groups, but 48h after transplantation s1L-2Ra level was 1020 Pg/ml in successful renal transplant and 1440 in ACUTE REJECTION group with a statistical difference (P<0.02). In addition in ACUTE REJECTION, 48h after transplantation, the mean s1L-2Ra concentration showed statistical significant increase compared with before transplantation (P<0.05). The mean level of sIL-2Ra in ACUTE REJECTION group at the time of rejection crisis was 1808 Pg/ml and had significant difference in comparison with control group (P<0.001) and successful transplant group (P<0.005).The comparison of sIL-2Ra concentration between successful transplant and ACUTE REJECTION groups showed that the maximum level was "observed at the time of rejection attacks (in ACUTE REJECTION) and the minimum level was found in successful renal transplant befor transplantation (P<0.001).We concluded that at the first: sIL-2Ra in uremic patients (hemodialysis) is higher than healthy subjects and the second: follow up evaluation of sIL-2Ra had also predictive value with 85% sensitivity and 67% specificity at cut off 1000 P g/ml, but, increased level of creatinin is obseved only at the time of clinical diagnosis of ACUTE REJECTION so that the predictive value of creatinin level is lower.

Cites

LABORATORY FINDINGS IN SUCCESSFUL AND REJECTED KIDNEY TRANSPLANTATION

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APA: Copy

NAGHIBI, M., HASAN NIYA, T., MOJAHEDI, M.J., REZAEEI, A., BEHROZ AGHDAM, A., & FARID HOSSINI, R.. (2001). A STUDY OF DIAGNOSTIC & PREDICTIVE VALUE OF SERUM SOLUBLE INTERLEUKIN-2 RECEPTOR A (SIL-2A) ON ACUTE REJECTION OF RENAL TRANSPLANTATION. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 44(72), 21-27. SID. https://sid.ir/paper/51776/en

Vancouver: Copy

NAGHIBI M., HASAN NIYA T., MOJAHEDI M.J., REZAEEI A., BEHROZ AGHDAM A., FARID HOSSINI R.. A STUDY OF DIAGNOSTIC & PREDICTIVE VALUE OF SERUM SOLUBLE INTERLEUKIN-2 RECEPTOR A (SIL-2A) ON ACUTE REJECTION OF RENAL TRANSPLANTATION. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2001;44(72):21-27. Available from: https://sid.ir/paper/51776/en

IEEE: Copy

M. NAGHIBI, T. HASAN NIYA, M.J. MOJAHEDI, A. REZAEEI, A. BEHROZ AGHDAM, and R. FARID HOSSINI, “A STUDY OF DIAGNOSTIC & PREDICTIVE VALUE OF SERUM SOLUBLE INTERLEUKIN-2 RECEPTOR A (SIL-2A) ON ACUTE REJECTION OF RENAL TRANSPLANTATION,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 44, no. 72, pp. 21–27, 2001, [Online]. Available: https://sid.ir/paper/51776/en

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