LABORATORY FINDINGS IN SUCCESSFUL AND REJECTED KIDNEY TRANSPLANTATION

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NAGHIBI MASIH; HASAN NIA T.; NAZEMIAN FATEMEH; REZAEI S.A.R.; FARID HOSSEINI REZA; PISH NAMAZ R.

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Journal: MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES Year:2002 | Volume:45 | Issue:76 Page(s): 5-11

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Title

LABORATORY FINDINGS IN SUCCESSFUL AND REJECTED KIDNEY TRANSPLANTATION

Author(s)

Keywords

RENAL TRANSPLANTATIONQ3

ACUTE REJECTIONQ4

BUNQ2

URIC ACIDQ3

INTERLEUKIN 2 RECEPTORQ2

NEUTROPHILQ3

LYMPHOCYTEQ2

HEMATOLOGICAL FACTORSQ3

Abstract

RENAL TRANSPLANTATION has now become a preferred treatment modality for patients with end stage renal disease. Accurate recognition and treatment of rejection is major concern in the early post transplant period. This study is carried out to evaluate success of transplantation based on some laboratory findings.The results show that creatinine in both groups were meaningfully decreased 48 hours after transplantation (P<0.006). However average serum concentration of creatinine 48 hours after transplantation in the rejected group compared with the group with successful transplant was higher from a statistical viewpoint (P<0.04).Uric acid evaluation in both groups showed that the URIC ACID level difference before transplantation and 48 hours after transplantation was not meaningful It was interesting that in the successful transplant group, the serum URIC ACID level showed considerable statistical decrease 48 hours after operation (P<0.0001) in comparison with preoperative level.In this study, the result related to BUN showed a pattern like URIC ACID. Although in the case of BUN there was considerable decrease 48 hours after transplantation in the successful group (P<0.0001).The average amount of serum BUN 48 hours after transplantation in the rejected group was considerably more than the successful transplant group (P<0.001). No meaningful difference was observed in ,the total Count of WBC between two groups. Interestingly, it was observed that the total number of leukocyte was not influenced by rejection while the percentage of NEUTROPHIL and the total number of NEUTROPHILs in mm3 of blood were influenced by rejection, On the other hand, we know that transplant rejection is an immunological activity and it is expected that the number and percentage of LYMPHOCYTEs in circulation during transplant rejection to be increased.However surprisingly, in the rejected group, there was a meaningful decrease (P<0.006) in LYMPHOCYTE count 48 hours after transplantation. This may be because of the immunologic ally suppressive drugs. About monocytes, the number and percentage were not influenced by graft rejection.

Cites

CIVIL LIABILITY ARISING FROM REJECTION OF TRANSPLANTED ORGAN

References

A STUDY OF DIAGNOSTIC & PREDICTIVE VALUE OF SERUM SOLUBLE INTERLEUKIN-2 RECEPTOR A (SIL-2A) ON ACUTE REJECTION OF RENAL TRANSPLANTATION

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APA: Copy

NAGHIBI, MASIH, HASAN NIA, T., NAZEMIAN, FATEMEH, REZAEI, S.A.R., FARID HOSSEINI, REZA, & PISH NAMAZ, R.. (2002). LABORATORY FINDINGS IN SUCCESSFUL AND REJECTED KIDNEY TRANSPLANTATION. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 45(76), 5-11. SID. https://sid.ir/paper/52079/en

Vancouver: Copy

NAGHIBI MASIH, HASAN NIA T., NAZEMIAN FATEMEH, REZAEI S.A.R., FARID HOSSEINI REZA, PISH NAMAZ R.. LABORATORY FINDINGS IN SUCCESSFUL AND REJECTED KIDNEY TRANSPLANTATION. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2002;45(76):5-11. Available from: https://sid.ir/paper/52079/en

IEEE: Copy

MASIH NAGHIBI, T. HASAN NIA, FATEMEH NAZEMIAN, S.A.R. REZAEI, REZA FARID HOSSEINI, and R. PISH NAMAZ, “LABORATORY FINDINGS IN SUCCESSFUL AND REJECTED KIDNEY TRANSPLANTATION,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 45, no. 76, pp. 5–11, 2002, [Online]. Available: https://sid.ir/paper/52079/en

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