EVALUATION OF HYPOGONADISM WITH MAJOR THALASSEMIA

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RAJABIAN R.; ABOUTORABI ROBAB BEYGOM; BONAKDARAN SH.; BADIEI Z.; KHAJEH DALOUEI M.

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Journal: Medical Journal of Mashhad University of Medical Sciences Year:2006 | Volume:49 | Issue:91 Page(s): 35-38

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Title

EVALUATION OF HYPOGONADISM WITH MAJOR THALASSEMIA

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Keywords

THALASSEMIA MAJORQ3

HYPOGONADISMQ3

ENDOCRINE COMPLICATIONQ3

Abstract

Introduction: Although new treatments have prolonged survival and improved quality of life in the patients with major Thalassemia, ENDOCRINE COMPLICATIONs especially hypogonadotropic HYPOGONADISM still occur. The objective of this study is to determine prevalence and risk factors of HYPOGONADISM in 47 patients with major Thalassemia.Material and Methods: 47 patients with THALASSEMIA MAJOR aged 14 years and older were studied. Those who had any other problems were omitted from this study. Serum level of LH, FSH, Testosterone, Estradiol were measured and correlation with parameters including duration of transfusion, duration and dose of Desferal treatment, Ferreting level and pertinent clinical findings was evaluated and compared in groups of patients with and without HYPOGONADISM. Results: Short stature and underweight was seen in 68/1% of patients. Mean hight was 151 ± 10.2 and mean of weight was 43.5 ± 8.4 . Hypogonadotropic HYPOGONADISM was seen in 63/8 %. The prevalence of HYPOGONADISM was more in males than females (p= 0.025). No significant correlation was found between duration of transfusion, duration and dose of Desferal treatment and Ferretin level with HYPOGONADISM.Conclusion: ENDOCRINE COMPLICATIONs of Major Thalassemia is frequent and factors other than iron overload including zinc deficiency or genetic differences may influence susceptibility to HYPOGONADISM.

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APA: Copy

RAJABIAN, R., ABOUTORABI, ROBAB BEYGOM, BONAKDARAN, SH., BADIEI, Z., & KHAJEH DALOUEI, M.. (2006). EVALUATION OF HYPOGONADISM WITH MAJOR THALASSEMIA. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 49(91), 35-38. SID. https://sid.ir/paper/51828/en

Vancouver: Copy

RAJABIAN R., ABOUTORABI ROBAB BEYGOM, BONAKDARAN SH., BADIEI Z., KHAJEH DALOUEI M.. EVALUATION OF HYPOGONADISM WITH MAJOR THALASSEMIA. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;49(91):35-38. Available from: https://sid.ir/paper/51828/en

IEEE: Copy

R. RAJABIAN, ROBAB BEYGOM ABOUTORABI, SH. BONAKDARAN, Z. BADIEI, and M. KHAJEH DALOUEI, “EVALUATION OF HYPOGONADISM WITH MAJOR THALASSEMIA,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 49, no. 91, pp. 35–38, 2006, [Online]. Available: https://sid.ir/paper/51828/en

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