THE CHANGES OF STROMAL CHONDROITINE SULFATE IN BPH AND PROSTATE ADENOCARCINOMA

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SABZARI A.R.; KERMANI T.; ZARDAST M.; VARASTEH A.

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Journal: MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES Year:2006 | Volume:49 | Issue:91 Page(s): 43-48

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Title

THE CHANGES OF STROMAL CHONDROITINE SULFATE IN BPH AND PROSTATE ADENOCARCINOMA

Author(s)

SABZARI A.R. | KERMANI T. | ZARDAST M. | VARASTEH A. | Issue Writer Certificate

Keywords

ADENOCARCINOMAQ3

BPHQ3

CHONDROITIN SULFATEQ3

EXTRACELLULAR MATRIXQ3

PROSTATEQ3

Abstract

Introduction: Despite many studies, the base of formation of hyperplasia and malignancy is unknown. PROSTATE cancer is the second most common malignancy in men all over the world. The EXTRACELLULAR MATRIX (ECM) contains a number of macromolecules that may influence normal and neoplastic growth of tissues.The pericellular glycosaminoglycan CHONDROITIN SULFATE (GAG/Ch.s) has been ascribed roles in cell-cell adhesion, cellular matrix adhesion, cellular migration and embryological morphogenesis. In this research changes of concentration of ch.s in BPH and PROSTATE ADENOCARCINOMA studied. Material and Methods: Formalin-fixed samples of BPH and ADENOCARCINOMA were taken from patients by surgery (prostatectomy). According to their histological characteristics (with H-E staining), samples were confirmed as BPH or PROSTATE cancer by a pathologist. All samples were fixed in PBS-formalin, processed in standard laboratory protocols, and embedded in paraffin wax. Samples were sectioned in each 5 µm. Then critical electrolyte concentration (CEC) alcian blue staining (ph=5.8) was performed. Results: The concentration of GAG/chondroitin sulfate in ECM was significantly higher in denocarcinoma as compared to BPH especially in the stromal-epithelial interface. In BPH, luminal surfaces were moderately stained of ch.s but poorly stained of the adjacent fibromuscular stromal tissues or were not stained at all In ADENOCARCINOMA chs revealed an intense pricellular-staining pattern, the most intense staining was observed in the base membrane. Conclusion: Changes of concentration of GAG/ ch.s between BPH and ADENOCARCINOMA were totally different (and specific). The increased ch.s may be a response or requirement for epithelial growth or cell division. Therefore, the intensity of GAG/Ch.s in PROSTATE stroma may be a useful biomarker of disease progression in PROSTATE cancer.

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APA: Copy

SABZARI, A.R., KERMANI, T., ZARDAST, M., & VARASTEH, A.. (2006). THE CHANGES OF STROMAL CHONDROITINE SULFATE IN BPH AND PROSTATE ADENOCARCINOMA. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 49(91), 43-48. SID. https://sid.ir/paper/51830/en

Vancouver: Copy

SABZARI A.R., KERMANI T., ZARDAST M., VARASTEH A.. THE CHANGES OF STROMAL CHONDROITINE SULFATE IN BPH AND PROSTATE ADENOCARCINOMA. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;49(91):43-48. Available from: https://sid.ir/paper/51830/en

IEEE: Copy

A.R. SABZARI, T. KERMANI, M. ZARDAST, and A. VARASTEH, “THE CHANGES OF STROMAL CHONDROITINE SULFATE IN BPH AND PROSTATE ADENOCARCINOMA,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 49, no. 91, pp. 43–48, 2006, [Online]. Available: https://sid.ir/paper/51830/en

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