A STUDY OF FOLATE AND COBALAMIN DEFICIENCY IN ELDERLY BY DETERMINING A CUT-OFF POINT WITH LABORATORY MARKERS

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SHIRDEL A.; MANAVIFAR L.; NEJAT SHOKOUHI A.; SHAKERI M.T.; MAHJOUB M.

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Journal: MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES Year:2009 | Volume:52 | Issue:2 Page(s): 0-0

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Title

A STUDY OF FOLATE AND COBALAMIN DEFICIENCY IN ELDERLY BY DETERMINING A CUT-OFF POINT WITH LABORATORY MARKERS

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Keywords

CUTOFF POINTQ2

COBALAMINQ3

ELDERLYQ3

FOLATEQ2

HOMOCYSTEINQ2

Abstract

Introduction: Prevalence of FOLATE and COBALAMIN deficiency in ELDERLY is high. Determining a cut off point forlow and marginal levels of FOLATE and COBALAMIN deficiency before development of anemia or neurocognitive presentations in ELDERLY is essential.Materials and Methods: In this cross-sectional study 280 persons above 65 years old in the twelve regions of Mashhad city were admitted to Emam Reza (pbuh) hospital. They were physically examined by a general practitioner. Other data were obtained by questionnaire. Serum COBALAMIN and FOLATE level were analyzed by RIA method. 76 persons, who had COBALAMIN of 120-450 pg/ml and FOLATE of 1.5-7 ng/ml without any interfering factor for HOMOCYSTEIN (Hcy) measurement (creatinin>1.5g/dl, cigarette smoking and consuming certain kind of drugs) were analyzed for serum HOMOCYSTEIN by Elisa method. All collected data was statistically analyzed by SPSS software.Results: 48.7% of ELDERLY had hyperhomocysteinemia. Hcy was inversely correlated with COBALAMIN (p=0.001) and FOLATE below cut off point (p=0.044). For Hcy>15 mol/lm, cut off points for COBALAMIN and FOLATE deficiency were <330 pg/ml and <6.5 ng/ml respectively. Prevalence of COBALAMIN deficiency in low levels (<122 pg/ml) was 22.7% and in marginal levels (122-330 pg/ml) was 51.8%. Prevalence of FOLATE deficiency in low levels (<3 ng/ml) was 16.7% and in marginal levels (<6.5 ng/ml) was 64.2%.Conclusion: According to definition of cut off point, Prevalence of COBALAMIN & FOLATE deficiency especially in marginal levels was higher than which is recorded. It is recommended that before development of signs and symptoms and other complications of hyperhomocysteinemia, all ELDERLY patients undergoes screening for COBALAMIN and FOLATE deficiency in appropriate intervals.

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APA: Copy

SHIRDEL, A., MANAVIFAR, L., NEJAT SHOKOUHI, A., SHAKERI, M.T., & MAHJOUB, M.. (2009). A STUDY OF FOLATE AND COBALAMIN DEFICIENCY IN ELDERLY BY DETERMINING A CUT-OFF POINT WITH LABORATORY MARKERS. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 52(2), 0-0. SID. https://sid.ir/paper/51977/en

Vancouver: Copy

SHIRDEL A., MANAVIFAR L., NEJAT SHOKOUHI A., SHAKERI M.T., MAHJOUB M.. A STUDY OF FOLATE AND COBALAMIN DEFICIENCY IN ELDERLY BY DETERMINING A CUT-OFF POINT WITH LABORATORY MARKERS. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;52(2):0-0. Available from: https://sid.ir/paper/51977/en

IEEE: Copy

A. SHIRDEL, L. MANAVIFAR, A. NEJAT SHOKOUHI, M.T. SHAKERI, and M. MAHJOUB, “A STUDY OF FOLATE AND COBALAMIN DEFICIENCY IN ELDERLY BY DETERMINING A CUT-OFF POINT WITH LABORATORY MARKERS,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 52, no. 2, pp. 0–0, 2009, [Online]. Available: https://sid.ir/paper/51977/en

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