EFFICACY CITICOLINE IN STROKE PATIENTS

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ASHRAFIAN AMIRI H.; TOGHA M.; VOSOUGHI REZA; NIKKHAH K.

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Journal: Medical Journal of Mashhad University of Medical Sciences Year:2002 | Volume:45 | Issue:77 Page(s): 59-64

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Information Journal Paper

Title

EFFICACY CITICOLINE IN STROKE PATIENTS

Author(s)

ASHRAFIAN AMIRI H. | TOGHA M. | VOSOUGHI REZA | NIKKHAH K. | Issue Writer Certificate

Keywords

CITICOLINEQ3

STROKEQ2

TREATMENTQ3

Abstract

CITICOLINE (CDP-Choline) is an essential intermediate in the biosynthetic pathway of Phosphatidy1choline, and the later is a main component of neuronal membranes. Many experimental and few clinical studies showed the beneficial effect of CITICOLINE in cerebrovascular diseases, memory disturbances and cognitive disorders.The current trial was a case - control study in 60 (40 patients as the cases and 20 patients as controls) nondiabetic, 50-70 years old patients who had an ischemic STROKE in the MCA territory for the first time. CITICOLINE (500 mg/day/IV or IM) was administered in the first 24h of STROKE and continued for 4 weeks. Barthel Index measured the neurologic function of the patients in the first day, 4th week and eighth week.After 4 weeks patients in CITICOLINE group had significantly greater improvement of neurologic function (p=0/01). Patients with more severe disability (BI<45) had more improvement at the end of 4th and 8th week. (59,5 for CITICOLINE and 39,6 for control group (p=0.001). The percent of patients who had a full recovery (95) were greatly higher in CITICOLINE group at eighth week.This study suggests that CITICOLINE was effective in enhancing neuroligic recovery in STROKE patients especially in a subgroup of patients who had more disability at the beginning.

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APA: Copy

ASHRAFIAN AMIRI, H., TOGHA, M., VOSOUGHI, REZA, & NIKKHAH, K.. (2002). EFFICACY CITICOLINE IN STROKE PATIENTS. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 45(77), 59-64. SID. https://sid.ir/paper/52019/en

Vancouver: Copy

ASHRAFIAN AMIRI H., TOGHA M., VOSOUGHI REZA, NIKKHAH K.. EFFICACY CITICOLINE IN STROKE PATIENTS. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2002;45(77):59-64. Available from: https://sid.ir/paper/52019/en

IEEE: Copy

H. ASHRAFIAN AMIRI, M. TOGHA, REZA VOSOUGHI, and K. NIKKHAH, “EFFICACY CITICOLINE IN STROKE PATIENTS,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 45, no. 77, pp. 59–64, 2002, [Online]. Available: https://sid.ir/paper/52019/en

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