POTENTIAL ROLES OF NEUROGENESIS IN ALZHEIMER'S DISEASE

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NESERI FARZIN; AHMADZADEH AMIR MAHMOUD; SAHAB NEGAH SAJAD

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Journal: MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES Year:2017 | Volume:60 | Issue:3 Page(s): 549-566

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Title

POTENTIAL ROLES OF NEUROGENESIS IN ALZHEIMER'S DISEASE

Author(s)

NESERI FARZIN | AHMADZADEH AMIR MAHMOUD | SAHAB NEGAH SAJAD | Issue Writer Certificate

Keywords

NEUROGENESISQ2

ALZHEIMER'S DISEASEQ2

NEURAL STEM CELLSQ2

ENRICHED ENVIRONMENTQ1

Abstract

Introduction: ALZHEIMER'S DISEASE (AD) is the most common form of dementia among the elderly. Its pathohistological characteristics are the accumulation of extracellular β-amyloid protein and hyperphosphorylation of tau protein. This neurodegenerative disorder is assumed to start with synaptic dysfunction and chronic loss of neuronal cells. Researchers believe that NEUROGENESIS appears in adulthood; therefore, replacement of the lost neurons can represent a therapeutic approach for the management and improvement of AD. The developing field of stem cell biology offers great therapeutic potential for chronic neurological conditions such as AD, particularly if joined with a multitargeted therapeutic approach. It has been shown that ENRICHED ENVIRONMENT positively affects patients' cognitive behaviors through various mechanisms, including modulation of NEUROGENESIS. Conclusion: The current advancements in NEUROGENESIS, stem cells therapies, and environmental enrichment in AD are reviewed in this article, and the potential barriers to the use of these treatments for AD patients are discussed.

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APA: Copy

NESERI, FARZIN, AHMADZADEH, AMIR MAHMOUD, & SAHAB NEGAH, SAJAD. (2017). POTENTIAL ROLES OF NEUROGENESIS IN ALZHEIMER'S DISEASE. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 60(3 ), 549-566. SID. https://sid.ir/paper/52041/en

Vancouver: Copy

NESERI FARZIN, AHMADZADEH AMIR MAHMOUD, SAHAB NEGAH SAJAD. POTENTIAL ROLES OF NEUROGENESIS IN ALZHEIMER'S DISEASE. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;60(3 ):549-566. Available from: https://sid.ir/paper/52041/en

IEEE: Copy

FARZIN NESERI, AMIR MAHMOUD AHMADZADEH, and SAJAD SAHAB NEGAH, “POTENTIAL ROLES OF NEUROGENESIS IN ALZHEIMER'S DISEASE,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 60, no. 3 , pp. 549–566, 2017, [Online]. Available: https://sid.ir/paper/52041/en

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