LEUKOCYTE ADHESION DEFICIENCY

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BEHMANESH F.; BANI HASHEM A.A.

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Journal Paper

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Journal: MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES Year:2009 | Volume:51 | Issue:4 Page(s): 243-246

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Information Journal Paper

Title

LEUKOCYTE ADHESION DEFICIENCY

Author(s)

BEHMANESH F. | BANI HASHEM A.A. | Issue Writer Certificate

Keywords

LEUKOCYTEQ3

ADHESIONQ3

INTEGRINQ2

LEUKOCYTOSISQ2

Abstract

Introduction: LEUKOCYTE ADHESION deficiency (LAD) is a rare functional LEUKOCYTE disorder, which is divided into two separate types: LAD-1 and LAD-2. LAD-1 results from lack of b2 INTEGRIN molecules (CD11 & CD18) on the LEUKOCYTE cell surface. These molecules are essential for LEUKOCYTE ADHESION to endothelial cells and chemotaxis.The present case report is about a 42-month-old girl with recurrent otitis, pneumonia and gingivitis. On physical examination, patient was pale and malnourished. Multiple desquamated erythematous plagues were found on her body and extremities. Blood investigations revealed persistent LEUKOCYTOSIS with normal serum Immunoglobulin profile and complement. The diagnosis of LAD1 was made based on Flow cytometry finding; showing decreased in CD11 and CD18 markers of PMN a.Conclusion: When a patient has persistent LEUKOCYTOSIS and recurrent infections, investigation for the primary immune deficiency, specially LEUKOCYTE ADHESION deficiency must be considered.

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APA: Copy

BEHMANESH, F., & BANI HASHEM, A.A.. (2009). LEUKOCYTE ADHESION DEFICIENCY. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 51(4), 243-246. SID. https://sid.ir/paper/52100/en

Vancouver: Copy

BEHMANESH F., BANI HASHEM A.A.. LEUKOCYTE ADHESION DEFICIENCY. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;51(4):243-246. Available from: https://sid.ir/paper/52100/en

IEEE: Copy

F. BEHMANESH, and A.A. BANI HASHEM, “LEUKOCYTE ADHESION DEFICIENCY,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 51, no. 4, pp. 243–246, 2009, [Online]. Available: https://sid.ir/paper/52100/en

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