DIFFERENTIATION BETWEEN NODULAR HYPERPLASIA & ADENOCARCINOMA OF PROSTATEHY AGNOR STAINING

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SOBHANI A.R.; FAROKHI FARID

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Journal: Medical Journal of Mashhad University of Medical Sciences Year:2003 | Volume:45 | Issue:78 Page(s): 85-90

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Title

DIFFERENTIATION BETWEEN NODULAR HYPERPLASIA & ADENOCARCINOMA OF PROSTATEHY AGNOR STAINING

Author(s)

SOBHANI A.R. | FAROKHI FARID | Issue Writer Certificate

Keywords

AGNORQ4

PROSTATEQ2

NODULAR HYPERPLASIAQ4

ADENOCARCINOMAQ3

Abstract

In some instances, differentiation between benign & malignant prostatic leisions with light microscopy even by an expert pathologist is not possible. So we try to evaluate distinction between NODULAR HYPERPLASIA & ADENOCARCINOMA by AGNOR staining.This study was performed on paraffin blocks from 58 case of Transe Urethral Resection PROSTATEctomy (TURP) and open PROSTATEctomy, as below: NODULAR HYPERPLASIA (n=27), ADENOCARCINOMA (n=31).Then AGNOR staining was done and the mean number, size & regularity of AGNORs dots in hundred-cel1 count were investigated.In the NODULAR HYPERPLASIA, the mean number of AGNORs regions was 1,66/ per cells and in ADENOCARCINOMA it was 2.38.In Prostatic hyperplasia these dots show small & regular in border, while in carcinoma they are larger, pleomorphic and have irregular borders.The "NORs" are the chromatin regions with weak stain property, which contain ribosome's genes & some argyrophilic proteins. The nucleolus appears around NORs in the late telophase; the number & size of them are related to proliferation & division process of cells.The AGNOR stain can be used for differentiation between prostatic carcinoma & NODULAR HYPERPLASIA, but this method may not be as a reliable index for grading of prostatic ADENOCARCINOMA.

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APA: Copy

SOBHANI, A.R., & FAROKHI, FARID. (2003). DIFFERENTIATION BETWEEN NODULAR HYPERPLASIA & ADENOCARCINOMA OF PROSTATEHY AGNOR STAINING. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 45(78), 85-90. SID. https://sid.ir/paper/52218/en

Vancouver: Copy

SOBHANI A.R., FAROKHI FARID. DIFFERENTIATION BETWEEN NODULAR HYPERPLASIA & ADENOCARCINOMA OF PROSTATEHY AGNOR STAINING. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2003;45(78):85-90. Available from: https://sid.ir/paper/52218/en

IEEE: Copy

A.R. SOBHANI, and FARID FAROKHI, “DIFFERENTIATION BETWEEN NODULAR HYPERPLASIA & ADENOCARCINOMA OF PROSTATEHY AGNOR STAINING,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 45, no. 78, pp. 85–90, 2003, [Online]. Available: https://sid.ir/paper/52218/en

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