Evaluation of association between polymorphism of proxisome proliferator-activated receptor-α and coronary artery calcification in coronary artery disease patients

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Moeinian Morteza; Mosaffa Fateme; MOHAMMADPOUR AMIR HOOSHANG; Nazem Saeed; SADR NABAVI ARIANE

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Journal: Medical Journal of Mashhad University of Medical Sciences Year:2019 | Volume:62 | Issue:2 Page(s): 1420-1429

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Title

Evaluation of association between polymorphism of proxisome proliferator-activated receptor-α and coronary artery calcification in coronary artery disease patients

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Keywords

coronary artery calcification (CAC)Q1

coronary artery disease (CAD)Q1

peroxisome proliferator-activated receptors alpha (PPARα)Q1

Abstract

Introduction: In previous studies the association between PPARα gene polymorphism and coronary artery calcification (CAC) CAD and atherosclerosis have been demonstrated and, CAD has been shown to be a directly related to CAC. However, an association between PPARα gene polymorphism and CAC has not been studied in our population. The aim of this study was to evaluate a possible association between PPARα gene polymorphisms and CAC in CAD patients. Materials and Methods: A total of Ninety CAD patients and 90 controls enrolled in this study. Computed tomography (CT) angiography was performed for all subjects and CAC was analyzed in the left coronary, left main coronary, right coronary and circumflex arteries. Polymorphism of PPARα was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and possible associations between PPARα polymorphism and coronary artery calcification in CAD patients and healthy controls were investigated. Results: No significant differences in the allele frequencies (G, C) or genotypes (GG, GC) were found between the two groups (G = 84. 6% vs. C = 15. 4%; P = 0. 52) and (GG = 70. 1% vs. GC = 28. 9%; P = 0. 43), respectively. No significant differences were found between genotype or allele frequencies in patients or healthy control with different CAC (P = 0. 41). Conclusion: No significant association was found between allele – genotype frequencies in subjects with CAC.

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References

Correlation and predictive value of aortic root calcification markers with coronary artery calcification and obstructive coronary artery disease

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APA: Copy

Moeinian, Morteza, Mosaffa, Fateme, MOHAMMADPOUR, AMIR HOOSHANG, Nazem, Saeed, & SADR NABAVI, ARIANE. (2019). Evaluation of association between polymorphism of proxisome proliferator-activated receptor-α and coronary artery calcification in coronary artery disease patients. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 62(2 ), 1420-1429. SID. https://sid.ir/paper/52272/en

Vancouver: Copy

Moeinian Morteza, Mosaffa Fateme, MOHAMMADPOUR AMIR HOOSHANG, Nazem Saeed, SADR NABAVI ARIANE. Evaluation of association between polymorphism of proxisome proliferator-activated receptor-α and coronary artery calcification in coronary artery disease patients. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;62(2 ):1420-1429. Available from: https://sid.ir/paper/52272/en

IEEE: Copy

Morteza Moeinian, Fateme Mosaffa, AMIR HOOSHANG MOHAMMADPOUR, Saeed Nazem, and ARIANE SADR NABAVI, “Evaluation of association between polymorphism of proxisome proliferator-activated receptor-α and coronary artery calcification in coronary artery disease patients,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 62, no. 2 , pp. 1420–1429, 2019, [Online]. Available: https://sid.ir/paper/52272/en

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