IL- 12 GENE POLYMORPHISM IN TYPE I DIABETES MELITUS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MASOUD A.H.; KEYHANI A.A.H.; SHEYKH BAHAEI N.; SALEHI I.; VOJGANI MOHAMMAD; RAJAB ASAD ELAH; MASOUD MAHTAB; MASOUD A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Medical Journal of Mashhad University of Medical Sciences Year:2007 | Volume:50 | Issue:97 Page(s): 283-286

Download Full-Text

Persian Verion

View:

864

Download:

Cites:

Information Journal Paper

Title

IL- 12 GENE POLYMORPHISM IN TYPE I DIABETES MELITUS

Author(s)

Keywords

CYTOKINEQ3

POLYMORFISM IL-12 GENEQ3

TYP 1DIABETSQ2

INTERLEUKIN 12Q3

Abstract

Introduction: Type 1 diabetes is an autoimmune disease characterized by T-cell mediated destruction of pancreatic b-cells. A variety of environmental and genetic factors are involved in the development of the disease. IL-12 is a CYTOKINE secreted by different cells and plays and important role in cell-mediated immune responses and maintenance of CYTOKINE network balance. Genetic polymorphisms in the IL-12 gene were shown to interfere with the transcriptional activity of the IL-12 gene, and this influences the production, secretion or activity of IL-12 growth factor. In this study the polymorphism in the 3'-untranslated region of the IL12B gene encoding IL- 12p40 was investigated.Materials and Methods: in this case control study 75 type 1 diabetic patients who had definitely been diagnosed at least 2 years before sampling and were under Insulin therapy, recruited. A total of 88 healthy controls selected from voluntarily blood donors who had referred to IRAN Blood Transfusion Organization. DNA extracted from whole blood and polymorphism at +1188 nucleotide was assessed by SSP-PCR. Data were analyzed by SPSS, using chi- square test with 95% confidence interval.Results: A statistical significance of AA presence (57%) at the +1188 3'-UTR position of IL-12 B gene in patients was found, after genotyping, compared to the control group (p<0.05).Conclusion: Interleukin-12 (IL-12) is a key CYTOKINE for the induction of Thl immune responses. Polymorphism in the 3' -UTR of the IL-12 p40 gene and association with susceptibility to Diabetes type I evaluated. AA genotype was more frequent than AC and the AC more common than CC in diabetic patients. In another word, the A allele of the (A/C) polymorphism at position +1188in the 3'-UTR found to be preferentially transmitted to people with type I diabetes. These polymorphisms may affect gene transcription of IL-12 p40, causing individual variations in CYTOKINE production. A better understanding of the molecular mechanisms, will give us the opportunities to develop new and effective therapeutic approaches.

Cites

No record.

References

No record.

Cite

APA: Copy

MASOUD, A.H., KEYHANI, A.A.H., SHEYKH BAHAEI, N., SALEHI, I., VOJGANI, MOHAMMAD, RAJAB, ASAD ELAH, MASOUD, MAHTAB, & MASOUD, A.. (2007). IL- 12 GENE POLYMORPHISM IN TYPE I DIABETES MELITUS. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 50(97), 283-286. SID. https://sid.ir/paper/52326/en

Vancouver: Copy

MASOUD A.H., KEYHANI A.A.H., SHEYKH BAHAEI N., SALEHI I., VOJGANI MOHAMMAD, RAJAB ASAD ELAH, MASOUD MAHTAB, MASOUD A.. IL- 12 GENE POLYMORPHISM IN TYPE I DIABETES MELITUS. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;50(97):283-286. Available from: https://sid.ir/paper/52326/en

IEEE: Copy

A.H. MASOUD, A.A.H. KEYHANI, N. SHEYKH BAHAEI, I. SALEHI, MOHAMMAD VOJGANI, ASAD ELAH RAJAB, MAHTAB MASOUD, and A. MASOUD, “IL- 12 GENE POLYMORPHISM IN TYPE I DIABETES MELITUS,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 50, no. 97, pp. 283–286, 2007, [Online]. Available: https://sid.ir/paper/52326/en

Related Journal Papers