FORMULATION STABILITY AND EVALUATION OF PERCUTANEOUS ABSORPTION OF TOPICCAL SOLUTION OF MINOXIDIL AND MINOXIDIL-ETHYNIL ESTRADIOL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHARAVI S.M.; PARDAKHTY A.; HAGHIGHATZADEH L.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2001 | Volume:4 | Issue:2 (10) Page(s): 95-100

Download Full-Text

Persian Verion

View:

1,264

Download:

Cites:

Information Journal Paper

Title

FORMULATION STABILITY AND EVALUATION OF PERCUTANEOUS ABSORPTION OF TOPICCAL SOLUTION OF MINOXIDIL AND MINOXIDIL-ETHYNIL ESTRADIOL

Author(s)

GHARAVI S.M. | PARDAKHTY A. | HAGHIGHATZADEH L. | Issue Writer Certificate

Keywords

MINOXIDILQ3

ETHINYL ESTRADIOLQ4

AANDROGENIC ALOPECIAQ2

Abstract

In this study different formulations including 2% MINOXIDIL and 0.01% ETHINYL ESTRADIOL in a mixed solvents [ethanol, propylen glycol (pG) and water, with the ratio of 50: 20: 30] were prepared, and their stabilities were studied via accelerated tests. In this assessment some factors such as: presence or absence of light, effect of antioxidant agent and vehicle were considered. The degradation of two active ingredients was first-order reaction. By using antioxidant agents and amber glass as suitable containers, the length of their shelf-life was increased. In order to protect quick and high degradation rate of the ethynil estradiol and its concentration fluctuation, PG was omitted from the solvent system. In percutaneous absorption, kinetic of MINOXIDIL was zero-order reaction while the ethynil estradiol obeyed Higuchi's modle. Perhaps the high absorption rate of ethynil estradiol was duo to its low polarity.

Cites

No record.

References

No record.

Cite

APA: Copy

GHARAVI, S.M., PARDAKHTY, A., & HAGHIGHATZADEH, L.. (2001). FORMULATION STABILITY AND EVALUATION OF PERCUTANEOUS ABSORPTION OF TOPICCAL SOLUTION OF MINOXIDIL AND MINOXIDIL-ETHYNIL ESTRADIOL. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 4(2 (10)), 95-100. SID. https://sid.ir/paper/52358/en

Vancouver: Copy

GHARAVI S.M., PARDAKHTY A., HAGHIGHATZADEH L.. FORMULATION STABILITY AND EVALUATION OF PERCUTANEOUS ABSORPTION OF TOPICCAL SOLUTION OF MINOXIDIL AND MINOXIDIL-ETHYNIL ESTRADIOL. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2001;4(2 (10)):95-100. Available from: https://sid.ir/paper/52358/en

IEEE: Copy

S.M. GHARAVI, A. PARDAKHTY, and L. HAGHIGHATZADEH, “FORMULATION STABILITY AND EVALUATION OF PERCUTANEOUS ABSORPTION OF TOPICCAL SOLUTION OF MINOXIDIL AND MINOXIDIL-ETHYNIL ESTRADIOL,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 4, no. 2 (10), pp. 95–100, 2001, [Online]. Available: https://sid.ir/paper/52358/en

Related Journal Papers