THE FREQUENCY OF EPSTEIN - BARR VIRUS (EBV) EXPRESSION IN VARIOUS HISTOLOGICAL SUBTYPES OF HODGKIN'S LYMPHOMA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KATEBI M.; SHARIFI N.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2005 | Volume:8 | Issue:3 (27) Page(s): 202-207

Download Full-Text

Persian Verion

View:

1,378

Download:

225

Cites:

Information Journal Paper

Title

THE FREQUENCY OF EPSTEIN - BARR VIRUS (EBV) EXPRESSION IN VARIOUS HISTOLOGICAL SUBTYPES OF HODGKIN'S LYMPHOMA

Author(s)

KATEBI M. | SHARIFI N. | Issue Writer Certificate

Keywords

EPSTEIN - BARR VIRUSQ3

HODGKIN'S LYMPHOMAQ3

EBV ASSOCIATED HLQ2

IMMUNOHISTOCHEMISTRYQ2

Abstract

The incidence of HODGKIN'S LYMPHOMA (HL) shows marked heterogeneity according to age, gender, race, geographical state, socioeconomic position and histological subtypes. Recently, multiple studies in different countries have been applied by newer technologies such as IMMUNOHISTOCHEMISTRY (IHC) and polymerase chain reaction (PCR), being more familiar with the pathogenesis of this neoplasm. The Epstein-Barr virus (EBV) is detected with high incidence in HL cases, approximately 40-50% in developed countries and much more (up to 95% of cases) in developing countries. There is evidences that mixed cellularity (MC) HODGKIN'S LYMPHOMA is more likely to be EBV-associated which is against association of nodular sclerosis (NS) subtype. With regard to the geographical location of Iran and absence of similar documented research in our knowledge, it is need to perform studies like this.Materials and Methods: This study was done by IHC method with antibody against latent membrane protein-1 (LMP-1) antigen of EBV for assessment of relationship between EBV infection and parameters such as age, gender and histological subtype. We collected 30 paraffin section samples of classic HL and positive cytoplasmic reactivity of Reed-Steinberg (RS) cells was evaluated.Results: From 30 cases surveyed in this study only 2 cases were not immunoreactive for EBV marker of which both were NS subtype in two adult males. We confirm frequency of 93% EBV ASSOCIATED HL in our cases, and also confirm the above histological subtype distribution, and that childhood cases are more likely to be EBV-associated than adult cases. There is possible female predominance of EBV ASSOCIATED HL. This survey as a pilot study needs further studies with more cases for distinct confirmation.Conclusion: It seems that EBV is a strong etiologic factor especially in developing countries like Iran and in childhood cases.

Cites

No record.

References

No record.

Cite

APA: Copy

KATEBI, M., & SHARIFI, N.. (2005). THE FREQUENCY OF EPSTEIN - BARR VIRUS (EBV) EXPRESSION IN VARIOUS HISTOLOGICAL SUBTYPES OF HODGKIN'S LYMPHOMA. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 8(3 (27)), 202-207. SID. https://sid.ir/paper/52442/en

Vancouver: Copy

KATEBI M., SHARIFI N.. THE FREQUENCY OF EPSTEIN - BARR VIRUS (EBV) EXPRESSION IN VARIOUS HISTOLOGICAL SUBTYPES OF HODGKIN'S LYMPHOMA. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2005;8(3 (27)):202-207. Available from: https://sid.ir/paper/52442/en

IEEE: Copy

M. KATEBI, and N. SHARIFI, “THE FREQUENCY OF EPSTEIN - BARR VIRUS (EBV) EXPRESSION IN VARIOUS HISTOLOGICAL SUBTYPES OF HODGKIN'S LYMPHOMA,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 8, no. 3 (27), pp. 202–207, 2005, [Online]. Available: https://sid.ir/paper/52442/en

Related Journal Papers