ANALYSIS OF THE PRESENCE OF EPSTEIN-BARR VIRUS IN HODGKIN'S LYMPHOMA IN IRANIAN CHILDREN BY EBER IN SITU HYBRIDIZATION

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MOZAFARI LEILA; NAJAFIPOUR SOHRAB; MESHKIBAF MOHAMMAD HASAN; MORAVEJ ALI

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Journal: Pars Journal of Medical Sciences Year:2014 | Volume:12 | Issue:2 Page(s): 0-0

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Title

ANALYSIS OF THE PRESENCE OF EPSTEIN-BARR VIRUS IN HODGKIN'S LYMPHOMA IN IRANIAN CHILDREN BY EBER IN SITU HYBRIDIZATION

Author(s)

MOZAFARI LEILA | NAJAFIPOUR SOHRAB | MESHKIBAF MOHAMMAD HASAN | MORAVEJ ALI | Issue Writer Certificate

Keywords

EPSTEIN-BARR VIRUSQ1

HODGKIN'S LYMPHOMAQ3

IN SITU HYBRIDIZATIONQ2

EBERSQ2

Abstract

Background & Objectives: EPSTEIN-BARR VIRUS (EBV) is a tumorigenic herpes virus and belong to DNA viruses that infects and persists in B lymphocytes with in the majority of humans and is also associated with some of cases of Hodgkin lymphoma (HL). The aim of the present study was to investigate the presence of EPSTEIN-BARR VIRUS in HODGKIN'S LYMPHOMA in children.Materials & Methods: In this study, 16 formalin-fixed paraffin embedded blocks of HODGKIN'S LYMPHOMA tissue samples collected from the archive of pathology departments. The presence of RNA transcripts encoded by the virus were examined by EBERS IN SITU HYBRIDIZATION (EBERs-ISH).Results: From investigated sixteen formalin-fixed, paraffin-embedded samples of Hodgkin's disease (HD) by EBERS IN SITU HYBRIDIZATION, 12 samples were from male (75%) and 4 samples were from female (25%). Age range of patients was 4 -12 years (with a median of 8 years). In 12 specimens (75%) EPSTEIN-BARR VIRUS was present. The positive cases included 9 male samples (75%) and 3 female samples (75%). EPSTEIN-BARR VIRUS was present in different subtypes of HODGKIN'S LYMPHOMA.80% of Mixed Cellularity (MC), 67% of Nodular Sclerosis (NS) and 100% of Lymphocyte Predominance (LP) subtypes were positive. The presence of EPSTEIN-BARR VIRUS in the age groups of 4-7 and 8-12 years were 71.5% and 77.8%, respectively.Conclusion: Results show strong association between EPSTEIN-BARR VIRUS and Hodgkin lymphoma in children. EPSTEIN-BARR VIRUS and Hodgkin lymphoma association in Iranian children show similar pattern with other developing countries.

Cites

DETECTION OF EPSTEIN-BARR VIRUS IN HODGKIN'S LYMPHOMA SPECIMENS IN THE FARS PROVINCE IN 2016

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APA: Copy

MOZAFARI, LEILA, NAJAFIPOUR, SOHRAB, MESHKIBAF, MOHAMMAD HASAN, & MORAVEJ, ALI. (2014). ANALYSIS OF THE PRESENCE OF EPSTEIN-BARR VIRUS IN HODGKIN'S LYMPHOMA IN IRANIAN CHILDREN BY EBER IN SITU HYBRIDIZATION. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 12(2), 0-0. SID. https://sid.ir/paper/405931/en

Vancouver: Copy

MOZAFARI LEILA, NAJAFIPOUR SOHRAB, MESHKIBAF MOHAMMAD HASAN, MORAVEJ ALI. ANALYSIS OF THE PRESENCE OF EPSTEIN-BARR VIRUS IN HODGKIN'S LYMPHOMA IN IRANIAN CHILDREN BY EBER IN SITU HYBRIDIZATION. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2014;12(2):0-0. Available from: https://sid.ir/paper/405931/en

IEEE: Copy

LEILA MOZAFARI, SOHRAB NAJAFIPOUR, MOHAMMAD HASAN MESHKIBAF, and ALI MORAVEJ, “ANALYSIS OF THE PRESENCE OF EPSTEIN-BARR VIRUS IN HODGKIN'S LYMPHOMA IN IRANIAN CHILDREN BY EBER IN SITU HYBRIDIZATION,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 12, no. 2, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/405931/en

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