EFFECTS OF THE ROSMARINUS OFFICINALIS AERIAL PARTS ON MORPHINE WITHDRAWAL SYNDROME IN MICE

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HOSSEINZADEH H.; NOUR BAKHSH MAHNAZ

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Iranian Journal of Basic Medical Sciences Year:2002 | Volume:5 | Issue:2 (14) Page(s): 62-69

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Title

EFFECTS OF THE ROSMARINUS OFFICINALIS AERIAL PARTS ON MORPHINE WITHDRAWAL SYNDROME IN MICE

Author(s)

HOSSEINZADEH H. | NOUR BAKHSH MAHNAZ | Issue Writer Certificate

Keywords

ROSMARINUS OFFICINALISQ4

MORPHINE DEPENDENCEQ2

WITHDRAWAL SYNDROMEQ4

MEDICINAL PLANTSQ2

Abstract

Due to the interaction of ROSMARINUS OFFICINALIS with opioid system we decided to evaluate the effects of the aerial parts of this plant on WITHDRAWAL SYNDROME. Dependence was induced using subcutaneous injections of morphine (50,50 and 75 mg/kg) for 3 days. On day 4, morphine was injected2h before the intraperitoneal injection of naloxone. The number of episodes of jumping during the 30 minutes after injection of naloxone was considered as intensity of the WITHDRAWAL SYNDROME. The results indicated that the aqueous extracts at doses of 1.68 g/kg and 2.4 g.kg (i.p.) were pharmacologically equal to 5 mg/kg of diazepam in the inhibition of WITHDRAWAL SYNDROME. The ethanolic extract was less effective and only a dose of 0.96 g/kg reduced the number of jumping. Phytochemical study also indicated that only the aqueous extract has an alkaloid component. It is concluded that the aqueous and ethanolic extracts of R. officinalis aerial parts could diminish the WITHDRAWAL SYNDROME of morphine.

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APA: Copy

HOSSEINZADEH, H., & NOUR BAKHSH, MAHNAZ. (2002). EFFECTS OF THE ROSMARINUS OFFICINALIS AERIAL PARTS ON MORPHINE WITHDRAWAL SYNDROME IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 5(2 (14)), 62-69. SID. https://sid.ir/paper/52456/en

Vancouver: Copy

HOSSEINZADEH H., NOUR BAKHSH MAHNAZ. EFFECTS OF THE ROSMARINUS OFFICINALIS AERIAL PARTS ON MORPHINE WITHDRAWAL SYNDROME IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2002;5(2 (14)):62-69. Available from: https://sid.ir/paper/52456/en

IEEE: Copy

H. HOSSEINZADEH, and MAHNAZ NOUR BAKHSH, “EFFECTS OF THE ROSMARINUS OFFICINALIS AERIAL PARTS ON MORPHINE WITHDRAWAL SYNDROME IN MICE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 5, no. 2 (14), pp. 62–69, 2002, [Online]. Available: https://sid.ir/paper/52456/en

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