COMPARISON BETWEEN THE INSULINOTROPIC EFFECTS OF MILRINONE AND AMRINONE, SELECTIVE PDE3 INHIBITORS IN IN-VITRO AND IN-VIVO CONDITIONS

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PARIZADEH S.M.R.; ZAHRAEI M.

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Journal: Iranian Journal of Basic Medical Sciences Year:2001 | Volume:4 | Issue:1 (9) Page(s): 7-15

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Information Journal Paper

Title

COMPARISON BETWEEN THE INSULINOTROPIC EFFECTS OF MILRINONE AND AMRINONE, SELECTIVE PDE3 INHIBITORS IN IN-VITRO AND IN-VIVO CONDITIONS

Author(s)

PARIZADEH S.M.R. | | ZAHRAEI M. | Issue Writer Certificate

Keywords

MILRINONEQ4

AMRINONEQ4

ISLETQ4

INSULIN-SECRETIONQ4

PHOSPHODIESTERASEQ4

PDE INHIBITIONQ4

Abstract

In the present study, the effects of MILRINONE and AMRINONE, selectivePDE3 inhibitors, on insulin secretion have been investigated, using in-vitro static (incubation of rat ISLETs and CRI- D2 cultured insulin secreting cells) and dynamic methods (islets perifusion) and in-vivo procedures. In incubation of the ISLETs, 10mMof glucose increased the insulin secretion and 10-4 MMILRINONE augmented glucose- induced insulin secretion significantly (P<0.05). But the effect of AMRINONE, another selective PDE3 inhibitor, was not significant. MILRINONE increased 10 mM glucose induced insulin secretion in a dose-dependent manner (EC509 =µ M). However, in the same conditions, the different concentration of AMRINONE did not produce a significant effect. In the presence of 3mM glucose, the amount of insulin which was released by CRI-D2 cells was very low and 10mM glucose did not increase insulin secretion significantly. But addition of 10-4MMILRINONE to 10mM glucose increased the amount of insulin release. In in-vivo experiments, MILRINONE increased plasma insulin concentration in a dose dependent manner (P<0.05). While AMRINONE, with the same concentrations, not only failed to increase insulin secretion, but it seemed to have a decreasing effect, although the effects were not significant (p>0.05). Considering the differences between MILRINONE and AMRINONE IC50 for PDE3 activity inhibition in other publications, we may conclude that the difference between the effects of MILRINONE and AMRINONE on insulin secretion is because of their IC50. The effects of MILRINONE confirm the insulinotropic effect of selective PDE3 inhibitor drugs. In comparison with the MILRINONE effects, the different effect of AMRINONE might be because of variations in PDE inhibitor effects among different tissues (tissue specificity) or existence of other mechanisms in augmentation of glucose-induced insulin release by selective PDE3 inhibitors.

Cites

ANTI-HYPERGLYCEMIC EFFECTS OF CYCLIC NUCLEOTIDES PHOSPHODIESTERASES (PDES) IN RAT

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APA: Copy

PARIZADEH, S.M.R., ZAHRAEI, M.. (2001). COMPARISON BETWEEN THE INSULINOTROPIC EFFECTS OF MILRINONE AND AMRINONE, SELECTIVE PDE3 INHIBITORS IN IN-VITRO AND IN-VIVO CONDITIONS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 4(1 (9)), 7-15. SID. https://sid.ir/paper/52473/en

Vancouver: Copy

PARIZADEH S.M.R., ZAHRAEI M.. COMPARISON BETWEEN THE INSULINOTROPIC EFFECTS OF MILRINONE AND AMRINONE, SELECTIVE PDE3 INHIBITORS IN IN-VITRO AND IN-VIVO CONDITIONS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2001;4(1 (9)):7-15. Available from: https://sid.ir/paper/52473/en

IEEE: Copy

S.M.R. PARIZADEH, M. ZAHRAEI, “COMPARISON BETWEEN THE INSULINOTROPIC EFFECTS OF MILRINONE AND AMRINONE, SELECTIVE PDE3 INHIBITORS IN IN-VITRO AND IN-VIVO CONDITIONS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 4, no. 1 (9), pp. 7–15, 2001, [Online]. Available: https://sid.ir/paper/52473/en

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