THE EFFECTS OF TOPICAL APPLICATION OF OCTYL-2-CYANOACRYLATE TISSUE GLUE ON THE WOUND HEALING IN MICE: AN EXPERIMENTAL STUDY

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GHADERI R.; AFSHAR M.

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Journal: Iranian Journal of Basic Medical Sciences Year:2006 | Volume:9 | Issue:2 (30) Page(s): 136-143

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Title

THE EFFECTS OF TOPICAL APPLICATION OF OCTYL-2-CYANOACRYLATE TISSUE GLUE ON THE WOUND HEALING IN MICE: AN EXPERIMENTAL STUDY

Author(s)

GHADERI R. | AFSHAR M. | Issue Writer Certificate

Keywords

MICEQ2

OCAQ3

RESILIENCEQ3

WOUND HEALINGQ2

Abstract

Objective: Management of patients with full thickness wound of skin continues to challenge physicians and surgeons in area of cosmetic dermatologic surgery. At the present time, there are some medications and procedures that can be used to accelerate the healing of full thickness wound of skin. Based on studies that have demonstrated improved upper eyelid WOUND HEALING with OCA (octyl-2-cyanoacrylate tissue glue) treatment, we anticipated that OCA will accelerate healing of full thickness wound of skin. The aim of research is to evaluate the efficacy of OCA in accelerating healing of full thickness wound of skin in MICE.Materials and Methods: Design: experimental study, Animals: Male N. mRi MICE, Sample size: 6 per study group. Surgery: two mm full thickness wound of skin back of MICE under general anesthesia. Treatment groups: Control group: simple dressing with sterile guaze, OCA group: topical application octyl-2-cyanoacrylate (Derma bond; Ethic on Inc, Somerville, NJ) tissue glue. Study Period: MICE were euthanized on days 4, 7 and 10 post-operation to reflect different phases of WOUND HEALING, Assay: 1- gross pathology of the skin noting presence of infections, dehiscence and repair, 2- histological evaluation of the wound site for the degree of healing, 3 finally the wounds were tested for, RESILIENCE = ability of the wound to stretch and then resume shape without incurring any tissue damage, ultimate strength = maximum pressure a wound can tolerate before it starts to weaken and toughness = total amount of pressure a wound can tolerate before rupturing.Results: OCA increased: 1) formation of granulation tissue 2) density and activation of fibroblasts 3) keratinization in surface of wound 4) thickness of basement membrane and epidermis. OCA decreased infection, inflammation, edema and dehiscence. Finally OCA increased RESILIENCE, ultimate strength and toughness of wound in MICE.Conclusion: We conclude that OCA accelerates healing of full thickness wound of skin in MICE

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APA: Copy

GHADERI, R., & AFSHAR, M.. (2006). THE EFFECTS OF TOPICAL APPLICATION OF OCTYL-2-CYANOACRYLATE TISSUE GLUE ON THE WOUND HEALING IN MICE: AN EXPERIMENTAL STUDY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 9(2 (30)), 136-143. SID. https://sid.ir/paper/52498/en

Vancouver: Copy

GHADERI R., AFSHAR M.. THE EFFECTS OF TOPICAL APPLICATION OF OCTYL-2-CYANOACRYLATE TISSUE GLUE ON THE WOUND HEALING IN MICE: AN EXPERIMENTAL STUDY. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2006;9(2 (30)):136-143. Available from: https://sid.ir/paper/52498/en

IEEE: Copy

R. GHADERI, and M. AFSHAR, “THE EFFECTS OF TOPICAL APPLICATION OF OCTYL-2-CYANOACRYLATE TISSUE GLUE ON THE WOUND HEALING IN MICE: AN EXPERIMENTAL STUDY,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 9, no. 2 (30), pp. 136–143, 2006, [Online]. Available: https://sid.ir/paper/52498/en

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