ROLE OF TERMINAL GLYCOCONJUGATE MOLECULES DURING DEVELOPMENT OF THE DORSAL ROOT GANGLIA

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JAFARPOUR M.; FAZEL A.R.

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Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2000 | Volume:3 | Issue:2 (7) Page(s): 76-82

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Title

ROLE OF TERMINAL GLYCOCONJUGATE MOLECULES DURING DEVELOPMENT OF THE DORSAL ROOT GANGLIA

Author(s)

JAFARPOUR M. | FAZEL A.R. | Issue Writer Certificate

Keywords

NEURAL CRESTQ4

LECTIN HISTOCHEMISTRYQ3

GANGLIOGENESISQ4

DORSAL ROOT GANGLIAQ4

Abstract

Dorsal root ganglia of spinal nerves are derivates from NEURAL CREST. After beginning of ventral migration, some NEURAL CREST cells produce cell clusters on both sides of spinal cords. These cells form DORSAL ROOT GANGLIA during the development. Investigations about the way of migration and key factors for promotion of cells toward a target are scanty. Substance that switch development of ganglia were unknown too. In this search the pattern of migration and ganglionic development have been studied. By using specialized lectins for specific terminal sugar modulation of glycoconjugates was studied. Fetuses were selected from pregnant rats, from 9th to 20th day of gestation. A few newborn were also elected for the same experiments. It appears that Gal Nac terminal sugar was key substance for migration and development of cells during migration. This terminal sugar has specific reaction with SBA lectin. It was found that Fucose molecule 1→6 terminal sugar might be key factor for development and morphogenesis of cellular constitution of DORSAL ROOT GANGLIA. This sugar was reacted with OFA lectin specific for 1→6 linkage of fucose to penultimate sugar of glycoconjugate chain.

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APA: Copy

JAFARPOUR, M., & FAZEL, A.R.. (2000). ROLE OF TERMINAL GLYCOCONJUGATE MOLECULES DURING DEVELOPMENT OF THE DORSAL ROOT GANGLIA. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 3(2 (7)), 76-82. SID. https://sid.ir/paper/52516/en

Vancouver: Copy

JAFARPOUR M., FAZEL A.R.. ROLE OF TERMINAL GLYCOCONJUGATE MOLECULES DURING DEVELOPMENT OF THE DORSAL ROOT GANGLIA. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2000;3(2 (7)):76-82. Available from: https://sid.ir/paper/52516/en

IEEE: Copy

M. JAFARPOUR, and A.R. FAZEL, “ROLE OF TERMINAL GLYCOCONJUGATE MOLECULES DURING DEVELOPMENT OF THE DORSAL ROOT GANGLIA,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 3, no. 2 (7), pp. 76–82, 2000, [Online]. Available: https://sid.ir/paper/52516/en

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