THE EFFICACY OF INTERFERON-Α IN THE TREATMENT OF MULTIDRUG RESISTANT TUBERCULOSIS

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MANSOURI S.D.; TAVANA S.; MIRSAEIDI SEYED MAHDI; YAZDAN PANAH M.; SOHRABPOUR H.

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Journal: TANAFFOS Year:2002 | Volume:1 | Issue:3 Page(s): 29-34

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Title

THE EFFICACY OF INTERFERON-Α IN THE TREATMENT OF MULTIDRUG RESISTANT TUBERCULOSIS

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Keywords

MULTIDRUG-RESISTANT TUBERCULOSISQ4

ANTI-TUBERCULOSIS DRUGSQ4

INTERFERONQ4

Abstract

Background: Tuberculosis is a major cause of infectious disease mortality all over the world. Multidrug resistant tuberculosis (MDR-TB) is a major problem in the management of tuberculosis. With recent advances in understanding the immunopathogenesis of tuberculosis, the use of various cytokine therapies has been suggested. The objective of this study was to evaluate the efficacy of parenteral INF– for treating MDR-TB patients.Materials and Methods: To conduct the study, 12 MDR- TB patients hospitalised in the clinical mycobacteriology ward of Massih Daneshvari hospital were selected randomly between October 2000 and March 2001. All had chest involvement in radiography, so they were smear and culture positive on two occasions. All had at least resistance to isoniazid and rifampin in antibiogram. They were divided in two groups. One group received INF-; (3,000,000U, three times a week, subcutaneously) in addition to anti-TB drugs, and the other group received only anti -TB medications as control group.Results: Results indicate that the mean (±SD) degree of sputum smear positivity at the beginning of therapy was 2.4±0.89 in the case group and 2±0.89 in the control group which showed no significant difference (p= 0.132). Also, at the beginning of our study, there was no significant difference in the degree of sputum culture positivity between the two groups. At the end of the 8th week, all cases became smear and culture negative, but all control subjects remained smear and culture positive (p= 0.017). At the end of the 6th month; however, only two cases remained smear negative, one remained culture negative and the rest became positive. All control subjects had positive culture results (p= 0.693).Conclusion: We conclude that cytokines have at least temporary effect on disease remission and can be used as adjunctive therapy.

Cites

THE STUDY OF TH1/TH2 CYTOKINE PROFILES (IL-10, IL-12, IL-4, AND IFNΓ) IN PBMCS OF PATIENTS WITH MULTIDRUG RESISTANT TUBERCULOSIS AND NEWLY DIAGNOSED DRUG RESPONSIVE CASES

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APA: Copy

MANSOURI, S.D., TAVANA, S., MIRSAEIDI, SEYED MAHDI, YAZDAN PANAH, M., & SOHRABPOUR, H.. (2002). THE EFFICACY OF INTERFERON-Α IN THE TREATMENT OF MULTIDRUG RESISTANT TUBERCULOSIS. TANAFFOS, 1(3), 29-34. SID. https://sid.ir/paper/52641/en

Vancouver: Copy

MANSOURI S.D., TAVANA S., MIRSAEIDI SEYED MAHDI, YAZDAN PANAH M., SOHRABPOUR H.. THE EFFICACY OF INTERFERON-Α IN THE TREATMENT OF MULTIDRUG RESISTANT TUBERCULOSIS. TANAFFOS[Internet]. 2002;1(3):29-34. Available from: https://sid.ir/paper/52641/en

IEEE: Copy

S.D. MANSOURI, S. TAVANA, SEYED MAHDI MIRSAEIDI, M. YAZDAN PANAH, and H. SOHRABPOUR, “THE EFFICACY OF INTERFERON-Α IN THE TREATMENT OF MULTIDRUG RESISTANT TUBERCULOSIS,” TANAFFOS, vol. 1, no. 3, pp. 29–34, 2002, [Online]. Available: https://sid.ir/paper/52641/en

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