SERODIAGNOSIS OF TUBERCULOSIS IN CHILDREN USING A60 ANTIGEN

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KHALILZADEH S.; YAZDANPANAH M.; BAGHIEI N.; HOSSEINI M.; VELAYATI A.A.; MASJEDI M.R.

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Journal: TANAFFOS Year:2002 | Volume:1 | Issue:2 Page(s): 15-19

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Title

SERODIAGNOSIS OF TUBERCULOSIS IN CHILDREN USING A60 ANTIGEN

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Keywords

A60 ANTIGENQ4

TUBERCULOSIS (TB)Q4

ELISAQ4

CHILDRENQ4

Abstract

Background: Measurement of antimycobacterial antibody may be used as an accurate diagnostic tool in childhood tuberculosis. Materials and Methods: This study was conducted to evaluate the value of IgG, IgA, and IgM levels against A60 ANTIGEN by using ELISA method for diagnosis of tuberculosis. 238 CHILDREN aged from 6 months to 18 years old, divided into 4 groups; group A(n=51),patients with documented diagnosis of tuberculosis ;group B (n=75), patients who had close contact with TB patients; group C (n=51), patients with lung diseases other than tuberculosis; group D(n=40), healthy CHILDREN .Serums of 4 different groups of patients were studied.Results: Group A consisted of 22 smear positive, 24 smear negative, and 5 extrapulmonary tuberculosis patients. Sensitivity for bacteriologic study in smear positive cases was 51.2%. The mean levels of IgG, IgA, and IgM were significantly high in group A compared to other groups. IgM anti-A60 antibody had 70.6% sensitivity and 62% specificity for tuberculosis. Among the smear negative tuberculosis patients IgM anti-A60 had a sensitivity of 62.1%. Sensitivity of IgM anti-A60 in group B was 53.3% .The sensitivity of combined use of IgG and IgM was 70.6% in group A. Conclusion: The sensitivity of serologic diagnosis of A60 ANTIGEN is higher than bacteriologic findings (77.3% vs. 51.2%). A60-ELISA test is a simple and rapid diagnostic method, which can facilitate the diagnosis of tuberculosis.

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APA: Copy

KHALILZADEH, S., YAZDANPANAH, M., BAGHIEI, N., HOSSEINI, M., VELAYATI, A.A., & MASJEDI, M.R.. (2002). SERODIAGNOSIS OF TUBERCULOSIS IN CHILDREN USING A60 ANTIGEN. TANAFFOS, 1(2), 15-19. SID. https://sid.ir/paper/52663/en

Vancouver: Copy

KHALILZADEH S., YAZDANPANAH M., BAGHIEI N., HOSSEINI M., VELAYATI A.A., MASJEDI M.R.. SERODIAGNOSIS OF TUBERCULOSIS IN CHILDREN USING A60 ANTIGEN. TANAFFOS[Internet]. 2002;1(2):15-19. Available from: https://sid.ir/paper/52663/en

IEEE: Copy

S. KHALILZADEH, M. YAZDANPANAH, N. BAGHIEI, M. HOSSEINI, A.A. VELAYATI, and M.R. MASJEDI, “SERODIAGNOSIS OF TUBERCULOSIS IN CHILDREN USING A60 ANTIGEN,” TANAFFOS, vol. 1, no. 2, pp. 15–19, 2002, [Online]. Available: https://sid.ir/paper/52663/en

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