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Information Journal Paper

Title

THE ROLE OF ROTAVIRUS IN ACUTE GASTROENTERITIS AND MOLECULAR EPIDEMIOLOGY PATTERN OF ROTAVIRUS INFECTION IN HOSPITALIZED CHILDREN IN TEHRAN

Pages

  21-29

Abstract

 Backgrounds: ACUTE GASTROENTERITIS have now been stablished as the major public health problem in CHILDREN worlwide. Rotavirus is the most important etiological agent of dehydrating gastroenteritis among CHILDREN in industrialized and developing countries, is also major cause of CHILDREN malnutrition.Methods: Acollected of 1250 stool specimens from hospitalized CHILDREN < 5 years old with acute gastroentritis in Tehran from January 2002 to April 2004 were analysed for Rotaviruses and characterized by antigenic (IDEIA, LA) and genomic (ds RNA PAGE) methods.Results: Group A Rotaviruses were detected in 28.4% of patients fecal specimens.The majority of Rotavirus infections (70%) were occurred in CHILDREN< 2 years of age with peaks of infection in 6 to 12 months of age (p<0.005). Rotavirus diarrhea in males and females were 58.30% and 41.7% respectively (p>0.05). The highest of Rotavirus infections was in cool seasons with peaks of infection in the months of December, January and February (p<0.005). The study of clinical manifestations in Rotavirus gastroenteritis cases showed that most CHILDREN had fever, vomiting and dehydration and breast feeding had a protective action against Rotavirus infection (p<0.005). In this study the molecular epidemiology of Rotavirus infection was investigated. Ten different RNA electrophoretic patterns, 7 of long and 3 short profiles were detected in the study area. A long RNA pattern classified as LA was the prevalent electrophoretype among all of the types, that occurred throughout the period studied and in 0-5 years old, but the short patterns occurred only in <24 months of age during the cool seasons. Rotavirus infection was shown to be an important agent of winter diarrhea disease in hospitalized young CHILDREN in Tehran. Conclusion: The Results of this study in Tehran reinforces the need to immunizing of CHILDREN by evaluated vaccine. The data demonstrate epidemiologic differences between Rotavirus long and short electrophoretypes incidence.

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    APA: Copy

    MODARES, SHAHRZAD, RAHBARIMANESH, A.A., MODARES, SHAHAB, FAGHIHZADEH, S., JAMAFZON, F., & KARIMI, M.. (2005). THE ROLE OF ROTAVIRUS IN ACUTE GASTROENTERITIS AND MOLECULAR EPIDEMIOLOGY PATTERN OF ROTAVIRUS INFECTION IN HOSPITALIZED CHILDREN IN TEHRAN. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 10(29), 21-29. SID. https://sid.ir/paper/52751/en

    Vancouver: Copy

    MODARES SHAHRZAD, RAHBARIMANESH A.A., MODARES SHAHAB, FAGHIHZADEH S., JAMAFZON F., KARIMI M.. THE ROLE OF ROTAVIRUS IN ACUTE GASTROENTERITIS AND MOLECULAR EPIDEMIOLOGY PATTERN OF ROTAVIRUS INFECTION IN HOSPITALIZED CHILDREN IN TEHRAN. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2005;10(29):21-29. Available from: https://sid.ir/paper/52751/en

    IEEE: Copy

    SHAHRZAD MODARES, A.A. RAHBARIMANESH, SHAHAB MODARES, S. FAGHIHZADEH, F. JAMAFZON, and M. KARIMI, “THE ROLE OF ROTAVIRUS IN ACUTE GASTROENTERITIS AND MOLECULAR EPIDEMIOLOGY PATTERN OF ROTAVIRUS INFECTION IN HOSPITALIZED CHILDREN IN TEHRAN,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 10, no. 29, pp. 21–29, 2005, [Online]. Available: https://sid.ir/paper/52751/en

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