AN ASSESSMENT OF THE MODE OF DELIVERY AND POVIDONE-IODINE DISINFECTION AT DELIVERY ON CORD BLOOD SPOT THYROTROPIN LEVELS AND THE RATE OF HYPERTHYROTROPINEMIA IN AN IODINE-SUFFICIENT AREA

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ORDOUKHANI A.; MIRMIRAN PARVIN; HEDAYATI S.M.; NAJAFI R.; MOHARAMZADEH M.; OWLYA A.

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Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2004 | Volume:6 | Issue:3(SN 23) Page(s): 0-0

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Title

AN ASSESSMENT OF THE MODE OF DELIVERY AND POVIDONE-IODINE DISINFECTION AT DELIVERY ON CORD BLOOD SPOT THYROTROPIN LEVELS AND THE RATE OF HYPERTHYROTROPINEMIA IN AN IODINE-SUFFICIENT AREA

Author(s)

Keywords

SCREENING

NEONATE

THYROTROPIN

UMBLICAL CORD

POVIDONE-IODINE

CHLORHEXIDINE

HYPOTHYROIDISM

Abstract

Introduction: Controversies still exist regarding the effect of mode of delivery and use of maternal POVIDONE-IODINE (PVP-I) disinfection at delivery on TSH levels. In this report, these issues were assessed. Materials and Methods: Cord blood spot samples of all live born NEONATEs were collected since February 1998, in Tehran and Damavand, and TSH values 20 mU/L were considered as hyperthyrotropinemia (recalls). Data regarding vaginal (VGL) and caesarean section (CS) deliveries and PVP-I 10% and CHLORHEXIDINE (CHL) 0. 5% (non-iodinated disinfectant) was recorded. PVP-I was used between 50-150mL in some VGL and 200-300 mL in all CS deliveries. NEONATEs <37 weeks’ gestation and <2500 g of birth-weight were excluded from the study. Results: Up to August 2002, 30492 cord spot samples were collected and 326 (1. 07%) were recalled. Median (95%CI) TSH values in VGL-PVP-I (n=16284) was 5. 2 (5. 9-6. 1) and in VGL-CHL (n=4166) was 5. 2 (5. 8-6. 1) mU/L (p=0. 81). Median (95%CI) TSH in CS-PVP-I (n=10042) was 4. 8 (5. 2-5. 5) mU/L that was significantly lower than those of VGL groups (p<0. 001). Frequency distribution of recalls in VGL-PVP-I (202 of 16284) and VGL-CHL (49 of 4166) was similar (p=0. 74) and was significantly lower in CS-PVP-I (75 of 10042) as compared to VGL-PVP-I (p<0. 001) and VGL-CHL (p=0. 012). The odds ratio (95%CIOR) of recall occurrence in VGL-PVP-I was 1. 7 (1. 28-2. 18) and in VGL-CHL was 1. 6 (1. 10-2. 27) as compared to CS-PVP-I. Conclusion: PVP-I had no effect on the elevation of cord spot TSH levels and recall rate in our program. Instead, the mode of delivery played a more effective role on the elevation of TSH values and recall rate.

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APA: Copy

ORDOUKHANI, A., MIRMIRAN, PARVIN, HEDAYATI, S.M., NAJAFI, R., MOHARAMZADEH, M., & OWLYA, A.. (2004). AN ASSESSMENT OF THE MODE OF DELIVERY AND POVIDONE-IODINE DISINFECTION AT DELIVERY ON CORD BLOOD SPOT THYROTROPIN LEVELS AND THE RATE OF HYPERTHYROTROPINEMIA IN AN IODINE-SUFFICIENT AREA . IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 6(3(SN 23)), 0-0. SID. https://sid.ir/paper/527878/en

Vancouver: Copy

ORDOUKHANI A., MIRMIRAN PARVIN, HEDAYATI S.M., NAJAFI R., MOHARAMZADEH M., OWLYA A.. AN ASSESSMENT OF THE MODE OF DELIVERY AND POVIDONE-IODINE DISINFECTION AT DELIVERY ON CORD BLOOD SPOT THYROTROPIN LEVELS AND THE RATE OF HYPERTHYROTROPINEMIA IN AN IODINE-SUFFICIENT AREA . IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2004;6(3(SN 23)):0-0. Available from: https://sid.ir/paper/527878/en

IEEE: Copy

A. ORDOUKHANI, PARVIN MIRMIRAN, S.M. HEDAYATI, R. NAJAFI, M. MOHARAMZADEH, and A. OWLYA, “AN ASSESSMENT OF THE MODE OF DELIVERY AND POVIDONE-IODINE DISINFECTION AT DELIVERY ON CORD BLOOD SPOT THYROTROPIN LEVELS AND THE RATE OF HYPERTHYROTROPINEMIA IN AN IODINE-SUFFICIENT AREA ,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 6, no. 3(SN 23), pp. 0–0, 2004, [Online]. Available: https://sid.ir/paper/527878/en

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