ENHANCEMENT OF SUBUNIT INFLUENZA VACCINE WITH DIPHTHERIA-TETANUS-PERTUSIS (DPT) VACCINATION

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TAMIZI FAR H.

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Journal Paper

Paper Information

Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL Year:2002 | Volume:20 | Issue:65 Page(s): 41-45

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Title

ENHANCEMENT OF SUBUNIT INFLUENZA VACCINE WITH DIPHTHERIA-TETANUS-PERTUSIS (DPT) VACCINATION

Author(s)

TAMIZI FAR H.

Keywords

SUBUNIT VACCINE

INFLUENZA.ADJUVANT

DTP

IMMUNREESPONSE

Abstract

This experiment was carried out to examine the initial feasibility of immunizing children with inactivated influenza virus vaccine combined with diphtheria - tetanus -pertussis (DTP) vaccine. Three groups of Balb/C mice were immunized with subunit influenza vaccine in PBS, subunit vaccine mixed with DTP, and PBS alone as control. Three doses of vaccine were given 3 weeks apart and the antibody response and resistance to challenge infection were tested 3 weeks after the first and third immunizations.The results showed that the antibody response and immunity to challenge virus infection were significantly greater in mice given vaccine in DTP than in those given subunit vaccine in PBS. Comparison of the responses to graded doses of influenza subunit vaccine in PBS and DTP indicated that the vaccine in DTP was 250 times as effective in inducing serum antibody and protection as subunit vaccine in PBS. The enhancing activity of DTP probably owes to alum (Aluminum-hydroxide) and the antigen component of DPT vaccine.The results suggest that immunization of infants and children against influenza could be achieved through combining small amounts of influenza subunit antigen with DTP vaccines. Since the present results have been obtained from experiments with mice, and that the responses to vaccines, and adjuvants vary from one species to another, we recommend that this experiment be undertaken in human volunteers. Similar results in human should translate into the applicability of the same method for immunizing infants, children and other: high-risk groups against influenza.

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APA: Copy

TAMIZI FAR, H.. (2002). ENHANCEMENT OF SUBUNIT INFLUENZA VACCINE WITH DIPHTHERIA-TETANUS-PERTUSIS (DPT) VACCINATION. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 20(65), 41-45. SID. https://sid.ir/paper/528063/en

Vancouver: Copy

TAMIZI FAR H.. ENHANCEMENT OF SUBUNIT INFLUENZA VACCINE WITH DIPHTHERIA-TETANUS-PERTUSIS (DPT) VACCINATION. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2002;20(65):41-45. Available from: https://sid.ir/paper/528063/en

IEEE: Copy

H. TAMIZI FAR, “ENHANCEMENT OF SUBUNIT INFLUENZA VACCINE WITH DIPHTHERIA-TETANUS-PERTUSIS (DPT) VACCINATION,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 20, no. 65, pp. 41–45, 2002, [Online]. Available: https://sid.ir/paper/528063/en

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