THE ACTUAL AMOUNT OF ACTIVE HEPATITIS C IN ASYMPTOMATIC VOLUNTEER BLOOD DDONORS IN THE CITY OF ARDABIL

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HABIBZADEH SHAHRAM; DARGHAHI FARAMARZ; YAZDANBOD ABBAS; SAEED HOSSEINI ASL; GHIZILBASH BEHROUZ; CHOKHACHIZADEH OZRA; SODEIFI ALIREZA

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Journal: Iranian Journal of Infectious Diseases and Tropical Medicine Year:2015 | Volume:20 | Issue:69 Page(s): 17-22

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Title

THE ACTUAL AMOUNT OF ACTIVE HEPATITIS C IN ASYMPTOMATIC VOLUNTEER BLOOD DDONORS IN THE CITY OF ARDABIL

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Keywords

BLOOD DONORSQ3

HEPATITIS CQ3

ACTIVE INFECTIONQ2

ARDABILQ3

Abstract

Background and objectives: HEPATITIS C virus (HCV) is a, enveloped, single-stranded RNA virus of the family Flaviviridae, is transmitted primarily through contact with infected blood. After primary infection, approximately 80% of patients will have chronic disease. The study was conducted to determine active HEPATITIS C infection rate among ARDABIL city BLOOD DONORS.Materials and Methods: In this cross sectional study from all of donated blood samples during three years, cases that were positive in both: ELISA screening test and confirmatory specific RIBA test were studied. RT-PCR was used to confirm ACTIVE INFECTION.Results: All of the 55262 blood samples from 2009 to 2012 were evaluated. In 60, BLOOD DONORS screening HCV ELISA test were positive (0.01%). Confirmatory, specific RIBA test in 19 of them (31%) were positive. ELISA was falsely positive in about 70% of cases. Among 19 patients with positive RIBA test, polymerase chain reaction performed and in 12 of them (63%) ACTIVE INFECTION were documented.Conclusion: Probability of a positive PCR test in asymptomatic volunteer BLOOD DONORS with positive ELISA test was 20%. Only 63% of persons with true positive antibodies against HEPATITIS C (positive RIBA test) had positive RT-PCR test, so approximately 37% of infected patients have resolved spontaneously. Before disease labeling, it is necessary to confirm infection with performing specific RT-PCR test because ELISA test is falsely positive in some cases and positive RIBA test may be related to past spontaneously resolved infection.

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APA: Copy

HABIBZADEH, SHAHRAM, DARGHAHI, FARAMARZ, YAZDANBOD, ABBAS, SAEED HOSSEINI, ASL, GHIZILBASH, BEHROUZ, CHOKHACHIZADEH, OZRA, & SODEIFI, ALIREZA. (2015). THE ACTUAL AMOUNT OF ACTIVE HEPATITIS C IN ASYMPTOMATIC VOLUNTEER BLOOD DDONORS IN THE CITY OF ARDABIL. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 20(69), 17-22. SID. https://sid.ir/paper/52820/en

Vancouver: Copy

HABIBZADEH SHAHRAM, DARGHAHI FARAMARZ, YAZDANBOD ABBAS, SAEED HOSSEINI ASL, GHIZILBASH BEHROUZ, CHOKHACHIZADEH OZRA, SODEIFI ALIREZA. THE ACTUAL AMOUNT OF ACTIVE HEPATITIS C IN ASYMPTOMATIC VOLUNTEER BLOOD DDONORS IN THE CITY OF ARDABIL. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2015;20(69):17-22. Available from: https://sid.ir/paper/52820/en

IEEE: Copy

SHAHRAM HABIBZADEH, FARAMARZ DARGHAHI, ABBAS YAZDANBOD, ASL SAEED HOSSEINI, BEHROUZ GHIZILBASH, OZRA CHOKHACHIZADEH, and ALIREZA SODEIFI, “THE ACTUAL AMOUNT OF ACTIVE HEPATITIS C IN ASYMPTOMATIC VOLUNTEER BLOOD DDONORS IN THE CITY OF ARDABIL,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 20, no. 69, pp. 17–22, 2015, [Online]. Available: https://sid.ir/paper/52820/en

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