STUDY ON THE ANTICONVULSANT ACTIVITY OF THYMOQUINONE, THE MAJOR CONSTITUENT OF NIGELLA SATIVA L. SEEDS, THROUGH INTRACEREBROVENTRICULAR INJECTION

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PARVARDEH S.; NASIRIASL M.; MANSOURI M.T.; HOSSEINZADEH H.

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Journal: Journal of Medicinal Plants Year:2005 | Volume:4 | Issue:14 Page(s): 0-0

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Title

STUDY ON THE ANTICONVULSANT ACTIVITY OF THYMOQUINONE, THE MAJOR CONSTITUENT OF NIGELLA SATIVA L. SEEDS, THROUGH INTRACEREBROVENTRICULAR INJECTION

Author(s)

PARVARDEH S. | NASIRIASL M. | MANSOURI M.T. | HOSSEINZADEH H. | Issue Writer Certificate

Keywords

THYMOQUINONE

NIGELLA SATIVA

ANTICONVULSANT

PENTYLENETETRAZOLE

STEREOTAXY

Abstract

Background: THYMOQUINONE, the major constituent of NIGELLA SATIVA seeds, is a biologically active compound, which possesses several pharmacological effects. Objective: The aim of the present study was to evaluate the ANTICONVULSANT effect of THYMOQUINONE through intracerebroventricular (i.c.v.) injection. Method: The ANTICONVULSANT effects of THYMOQUINONE, the major constituent of NIGELLA SATIVA seeds, were investigated using PENTYLENETETRAZOLE (PTZ)-induced seizure model. Results: In PTZ-induced epileptic seizures, the i.c.v. injection of THYMOQUINONE (200 and 400 mol) prolonged the onset and reduced the duration of tonic-clonic seizures. The protective effect of THYMOQUINONE against lethality was 45% and 50% in the mentioned doses, respectively. In this study, flumazenil (1 nmol, i.c.v.) reversed the ANTICONVULSANT activity of THYMOQUINONE. Also, pretreatment with naloxone (10 mol, i.c.v.) antagonized the prolongation of tonic-clonic seizure latency, as well as reduction in seizure duration both induced by THYMOQUINONE (200 mol, i.c.v.). Conclusion: These results indicate that THYMOQUINONE may possess ANTICONVULSANT activity probably through an opioid receptor-mediated increase in GABAergic tone.

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APA: Copy

PARVARDEH, S., NASIRIASL, M., MANSOURI, M.T., & HOSSEINZADEH, H.. (2005). STUDY ON THE ANTICONVULSANT ACTIVITY OF THYMOQUINONE, THE MAJOR CONSTITUENT OF NIGELLA SATIVA L. SEEDS, THROUGH INTRACEREBROVENTRICULAR INJECTION. JOURNAL OF MEDICINAL PLANTS, 4(14), 0-0. SID. https://sid.ir/paper/528253/en

Vancouver: Copy

PARVARDEH S., NASIRIASL M., MANSOURI M.T., HOSSEINZADEH H.. STUDY ON THE ANTICONVULSANT ACTIVITY OF THYMOQUINONE, THE MAJOR CONSTITUENT OF NIGELLA SATIVA L. SEEDS, THROUGH INTRACEREBROVENTRICULAR INJECTION. JOURNAL OF MEDICINAL PLANTS[Internet]. 2005;4(14):0-0. Available from: https://sid.ir/paper/528253/en

IEEE: Copy

S. PARVARDEH, M. NASIRIASL, M.T. MANSOURI, and H. HOSSEINZADEH, “STUDY ON THE ANTICONVULSANT ACTIVITY OF THYMOQUINONE, THE MAJOR CONSTITUENT OF NIGELLA SATIVA L. SEEDS, THROUGH INTRACEREBROVENTRICULAR INJECTION,” JOURNAL OF MEDICINAL PLANTS, vol. 4, no. 14, pp. 0–0, 2005, [Online]. Available: https://sid.ir/paper/528253/en

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