COMPARATIVE EVALUATION BETWEEN TWO REGIMENS IN TREATMENT OF SMEAR POSITIVE PULMONARY TUBERCULOSIS HIGHLY SUSPECTED FOR MDR-TB

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ALAVI M.; YODYOD M.J.; SAIDI A.A.

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Journal: Iranian Journal of Infectious Diseases and Tropical Medicine Year:2006 | Volume:11 | Issue:32 Page(s): 23-28

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Title

COMPARATIVE EVALUATION BETWEEN TWO REGIMENS IN TREATMENT OF SMEAR POSITIVE PULMONARY TUBERCULOSIS HIGHLY SUSPECTED FOR MDR-TB

Author(s)

ALAVI M. | YODYOD M.J. | SAIDI A.A. | Issue Writer Certificate

Keywords

SMEAR POSITIVEQ3

PULMONARY TUBERCULOSISQ3

MDR-TBQ3

REGIMENSQ3

Abstract

Background: In the beginning 21st century tuberculosis is yet a global emergency. The main reason for this problem is emerging multi drug resistant Mycobacterium tuberculosis (MDR-TB). The strategy DOTS was offered to prevent MDR-TB but after 10 years it is yet a serious problem. We conducted this study for treating SMEAR POSITIVE PULMONARY TUBERCULOSIS who are at high risk to have MDR-TB such as progressing disease, large or multiple cavities, HIV positive patients, history of prisoning, and closed contact with known case of MDR-TB.Material and methods: This study is a comparative clinical trial study. Patients who took part in this study were divided in two groups. The first consists 25 patients and were treated by DOTS regimen. 10 patients in the other group were treated by our offered regimen. Duration for treatment and follow up was 18 months and 2years. Fisher exact test and spss 11.5 were used to compare results. Results: Conversion rate in sputum examination (positive to negative) at the end of 2, 5 ,9 and 18th, month in DOTS regimen were consequently 40%, 60% and 80%, but in our offered regimen were 70%, %90%, and 90% .There was no significant difference in effectiveness of treatment between two anti TB regimen (p=0.12). There was no difference in drug side effects between two groups. Conclusions: This study showed that although conversion rate of sputum in patients who were treated with our offered regimen was higher (90% versus 60%) and faster (after 5 months in contrast 9 months of treatment) than was DOTS, but statistically difference between this 2 REGIMENS is not significant ,so we recommend further clinical trials to achive better results.

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APA: Copy

ALAVI, M., YODYOD, M.J., & SAIDI, A.A.. (2006). COMPARATIVE EVALUATION BETWEEN TWO REGIMENS IN TREATMENT OF SMEAR POSITIVE PULMONARY TUBERCULOSIS HIGHLY SUSPECTED FOR MDR-TB. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 11(32), 23-28. SID. https://sid.ir/paper/52893/en

Vancouver: Copy

ALAVI M., YODYOD M.J., SAIDI A.A.. COMPARATIVE EVALUATION BETWEEN TWO REGIMENS IN TREATMENT OF SMEAR POSITIVE PULMONARY TUBERCULOSIS HIGHLY SUSPECTED FOR MDR-TB. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2006;11(32):23-28. Available from: https://sid.ir/paper/52893/en

IEEE: Copy

M. ALAVI, M.J. YODYOD, and A.A. SAIDI, “COMPARATIVE EVALUATION BETWEEN TWO REGIMENS IN TREATMENT OF SMEAR POSITIVE PULMONARY TUBERCULOSIS HIGHLY SUSPECTED FOR MDR-TB,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 11, no. 32, pp. 23–28, 2006, [Online]. Available: https://sid.ir/paper/52893/en

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