INHIBITION OF THEOPHYLLINE ELIMINATION BY NIFEDIPINE

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POURMOGHADAS M.; HOSHFAR GH.R.; MOGHAREABED A.R.

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Journal Paper

Paper Information

Journal: Journal of Isfahan Medical School Year:2003 | Volume:20 | Issue:69-70 (Special Issue, English) Page(s): 39-42

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Title

INHIBITION OF THEOPHYLLINE ELIMINATION BY NIFEDIPINE

Author(s)

POURMOGHADAS M. | HOSHFAR GH.R. | MOGHAREABED A.R.

Keywords

THEOPHYLLINE METABOLISM

INTERACTION

THEOPHYLLINE PHARMACOKINETICS

Abstract

INTRODUCTION: Theophylline has different INTERACTIONs with calcium antagonists. Significant INTERACTIONs between theophylline and diltiazem and to a lesser degree verapamil have been demonstrated, however, no data are available on the INTERACTION between theophylline and nifedipine. This study was conducted to investigate the effect of nifedipine therapy on THEOPHYLLINE PHARMACOKINETICS.METHODS: In order to investigate the effects of nifedipine on the pharmacokinetics of theophylline, intravenous aminophylline (400 mg) was administered to six healthy male nonsmokers prior to, and following 12 days of oral nifedipine therapy (30 mg/day). Liver and kidney function tests were performed to exclude subjects with hepatic or renal dysfunction. In addition, subjects receiving medications that could influence hepatic function or those known to inhibit or stimulate THEOPHYLLINE METABOLISM were excluded.RESULTS: Theophylline half-life increased significantly (36%)whereas total body clearance showed a significant decrease following nifedipine therapy (23%). Theophylline volume of distribution was changed.DISCUSSION: Inhibition of THEOPHYLLINE METABOLISM by nifedipine can partly explain significant changes in THEOPHYLLINE PHARMACOKINETICS. A clinically important

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APA: Copy

POURMOGHADAS, M., HOSHFAR, GH.R., & MOGHAREABED, A.R.. (2003). INHIBITION OF THEOPHYLLINE ELIMINATION BY NIFEDIPINE. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 20(69-70 (Special Issue, English)), 39-42. SID. https://sid.ir/paper/529302/en

Vancouver: Copy

POURMOGHADAS M., HOSHFAR GH.R., MOGHAREABED A.R.. INHIBITION OF THEOPHYLLINE ELIMINATION BY NIFEDIPINE. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2003;20(69-70 (Special Issue, English)):39-42. Available from: https://sid.ir/paper/529302/en

IEEE: Copy

M. POURMOGHADAS, GH.R. HOSHFAR, and A.R. MOGHAREABED, “INHIBITION OF THEOPHYLLINE ELIMINATION BY NIFEDIPINE,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 20, no. 69-70 (Special Issue, English), pp. 39–42, 2003, [Online]. Available: https://sid.ir/paper/529302/en

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