NATURAL YMDD MUTANTS IN CHRONIC B HEPATITIS

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RAMEZANI AMITIS; AGHAKHANI A.; BANIFAZL M.; HASANJANI ROSHAN M.R.; GACHKAR L.; KIVANI H.; YADEGARI D.; ESLAMIFAR A.; VELAYATI A.A.

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Journal: Iranian Journal of Infectious Diseases and Tropical Medicine Year:2007 | Volume:12 | Issue:37 Page(s): 1-6

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Title

NATURAL YMDD MUTANTS IN CHRONIC B HEPATITIS

Author(s)

Keywords

CHRONIC HEPATITISQ3

B HEPATITISQ3

LAMIVUDINEQ3

PCRQ3

YMDD MUTANTSQ3

Abstract

Background and objective: LAMIVUDINE (LAM) has been widely used as an effective antiviral agent for the treatment of patients with CHRONIC HEPATITIS B (CHB) infection. However, the YMDD motif mutation of HBV polymerase resistant to LAM occurs frequently after long term therapy.Recent studies show that YMDD motif mutants occur as natural genome variability in patients with CHB who had not been treated with LAM before. In this study we aimed to determine the rate of the YMDD motif mutants in LAMIVUDINE-untreated CHB patients in Iran.Material and methods: A total of 77 CHB patients who had not been treated with LAM were included in study. Serum samples from patients were tested by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) for detection of wild-type YMDD motif mutants. All patients were also tested for liver enzymes, Hepatitis C virus antibody (anti-HCV), hepatitis Be Antigen (HBeAg) and hepatitis B e antibody (anti-HBe).Results: From 77 patients enrolled in study, 73% were male and 27% were female with mean age 27.4±9.3 years. Mean ALT and AST levels in them were 124.4±73.4 and 103.1±81 IU/L respectively. HBeAg and anti-HBe was positive in 40% and 60% of patients respectively. Anti- HCV was negative in all of them. The YMDD motif mutants were not detected in any of the patients in spite of liver enzymes levels and HBeAg or anti-HBe presence.Conclusion: Although natural occurrence of YMDD motif mutants in LAMIVUDINE-untreated patients with CHB had been reported, these mutants were not detected in Iranian LAMIVUDINEuntreated CHB patients.

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APA: Copy

RAMEZANI, AMITIS, AGHAKHANI, A., BANIFAZL, M., HASANJANI ROSHAN, M.R., GACHKAR, L., KIVANI, H., YADEGARI, D., ESLAMIFAR, A., & VELAYATI, A.A.. (2007). NATURAL YMDD MUTANTS IN CHRONIC B HEPATITIS. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 12(37), 1-6. SID. https://sid.ir/paper/52964/en

Vancouver: Copy

RAMEZANI AMITIS, AGHAKHANI A., BANIFAZL M., HASANJANI ROSHAN M.R., GACHKAR L., KIVANI H., YADEGARI D., ESLAMIFAR A., VELAYATI A.A.. NATURAL YMDD MUTANTS IN CHRONIC B HEPATITIS. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2007;12(37):1-6. Available from: https://sid.ir/paper/52964/en

IEEE: Copy

AMITIS RAMEZANI, A. AGHAKHANI, M. BANIFAZL, M.R. HASANJANI ROSHAN, L. GACHKAR, H. KIVANI, D. YADEGARI, A. ESLAMIFAR, and A.A. VELAYATI, “NATURAL YMDD MUTANTS IN CHRONIC B HEPATITIS,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 12, no. 37, pp. 1–6, 2007, [Online]. Available: https://sid.ir/paper/52964/en

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