ASSOCIATION OF POLYMORPHISM OF HLA-DRBI *13 AND HLA-A *33 ALLELES WITH OUTCOME OF HEPATITIS B VIRUS INFECTION

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VELAYATI A.A.; AGHAKHANI A.; BANIFAZL M.; KALANTAR E.; ESLAMIFAR A.; KHADEMI Z.; RAMEZANI A.

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Journal: Iranian Journal of Infectious Diseases and Tropical Medicine Year:2009 | Volume:14 | Issue:46 Page(s): 11-14

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Title

ASSOCIATION OF POLYMORPHISM OF HLA-DRBI 13 AND HLA-A 33 ALLELES WITH OUTCOME OF HEPATITIS B VIRUS INFECTION

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Keywords

HEPATITIS BQ3

HUMAN LEUKOCYTE ANTIGEN (HLA)Q3

HIGH RESOLUTION PCR-SSPQ3

Abstract

Background and objective: The outcome of HEPATITIS B infection may be influenced by host factors like Human Leukocyte Antigen (HLA). We have investigated HLA-A and DRBI alleles in patients with persistent HEPATITIS B infection compared to subjects who had spontaneously recovered from HBV infection. To complete the findings of this study we performed another survey to determine predominant subtypes of HLA-A*33 and HLA-DRBI *13 alleles were associated with HBV infection outcomes.Materials and methods: Ninety-four HBV infected patients were enrolled in the study. First HLA-A and DRBI alleles were analyzed by using low resolution PCR sequence-specific-primer (PCR-SSP) and then we used HIGH RESOLUTION PCR-SSP method for sub typing HLA-A*33 and DRBI *13 alleles were significantly related to the outcome of HBV infection.Results: HLA-A*33 allele was significantly higher in persistent group than recovered group and sub typing showed HLA-A*3303 in 75% and HLA-A*330l in 25% of cases. HLA-DRBI *13 allele was significantly lower in persistent group than in recovered group and their subtypes were DRBI *1301 in 66.7% and DRBI *1303 in 33.3% of subjects.Conclusion: HLA-A*3303 and DRBI *1301 were the predominant HLA subtypes related to outcome of HBV infection. These findings emphasized that HLA is an important factor to determining the outcome of HBV infection.

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References

رابطه HLA کلاس I و II با پیش آگهی عفونت ویروس هپاتیت B

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APA: Copy

VELAYATI, A.A., AGHAKHANI, A., BANIFAZL, M., KALANTAR, E., ESLAMIFAR, A., KHADEMI, Z., & RAMEZANI, A.. (2009). ASSOCIATION OF POLYMORPHISM OF HLA-DRBI *13 AND HLA-A *33 ALLELES WITH OUTCOME OF HEPATITIS B VIRUS INFECTION. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 14(46), 11-14. SID. https://sid.ir/paper/52984/en

Vancouver: Copy

VELAYATI A.A., AGHAKHANI A., BANIFAZL M., KALANTAR E., ESLAMIFAR A., KHADEMI Z., RAMEZANI A.. ASSOCIATION OF POLYMORPHISM OF HLA-DRBI *13 AND HLA-A *33 ALLELES WITH OUTCOME OF HEPATITIS B VIRUS INFECTION. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2009;14(46):11-14. Available from: https://sid.ir/paper/52984/en

IEEE: Copy

A.A. VELAYATI, A. AGHAKHANI, M. BANIFAZL, E. KALANTAR, A. ESLAMIFAR, Z. KHADEMI, and A. RAMEZANI, “ASSOCIATION OF POLYMORPHISM OF HLA-DRBI *13 AND HLA-A *33 ALLELES WITH OUTCOME OF HEPATITIS B VIRUS INFECTION,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 14, no. 46, pp. 11–14, 2009, [Online]. Available: https://sid.ir/paper/52984/en

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