SUBTYPE MUTATIONS AND RELATED DRUG-RESISTANCE IN ANTI-RETROVIRAL TREATED HIV INFECTED PATIENTS

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RAMEZANI A.; HAMKAR R.; AGHAKHANI A.; LORESTANI SH.; BANIFAZL M.; TRUONG H.H.; MCFARLAND W.; FOROUGHI M.; ESLAMIFAR A.; MOHRAZ M.

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Journal: Iranian Journal of Infectious Diseases and Tropical Medicine Year:2010 | Volume:15 | Issue:50 Page(s): 1-7

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Title

SUBTYPE MUTATIONS AND RELATED DRUG-RESISTANCE IN ANTI-RETROVIRAL TREATED HIV INFECTED PATIENTS

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Keywords

HIVQ3

ANTIRETROVIRAL DRUGSQ3

DRUG RESISTANCEQ3

Abstract

Background and objective: Several studies have reported increasing number of therapeutic failures with ANTIRETROVIRAL DRUGS in HIV-infected patients. The emergence of viral resistant strains is a major problem for the medical management of infected individuals. The aim of this study is to determine viral subtypes and DRUG RESISTANCE mutations among antiretroviral-treated HIV- infected patients.Materials and methods: A total of 42 antiretroviral-treated HIV infected patients were enrolled. The HIV pol region were amplified and sequenced to determine subtypes and antiretroviral resistant mutations.Results: The subtype distribution was 48% A/D recombinants, 43% subtype B, 5% subtype A and 5% CRF01-AE recombinants. Drug resistant mutations were most common in subtype B (53%) and A/D recombinant strains (44%). Virus samples from 19% of participants had no drug resistant mutations; 2%, 2% and 76% of samples carried 1, 2 and ³3 drug resistant mutations, respectively. The prevalence of NRTI mutations was 76%, with M184V and L74V present in 60% and 38% of samples, respectively. The prevalence of NNRTI mutations was 74%, with P225H present in 55% of study specimens. The prevalence of PI mutations was 45%, with major mutation L90M seen in 33% and minor mutation A71V in 36% of samples.Conclusions: Our study found a high prevalence of drug resistant mutations in Iranian HIVinfected patients. Our data support the need for continued surveillance of resistance patterns to help guide therapeutic approaches and limit transmission of these variants.

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APA: Copy

RAMEZANI, A., HAMKAR, R., AGHAKHANI, A., LORESTANI, SH., BANIFAZL, M., TRUONG, H.H., MCFARLAND, W., FOROUGHI, M., ESLAMIFAR, A., & MOHRAZ, M.. (2010). SUBTYPE MUTATIONS AND RELATED DRUG-RESISTANCE IN ANTI-RETROVIRAL TREATED HIV INFECTED PATIENTS. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 15(50), 1-7. SID. https://sid.ir/paper/53004/en

Vancouver: Copy

RAMEZANI A., HAMKAR R., AGHAKHANI A., LORESTANI SH., BANIFAZL M., TRUONG H.H., MCFARLAND W., FOROUGHI M., ESLAMIFAR A., MOHRAZ M.. SUBTYPE MUTATIONS AND RELATED DRUG-RESISTANCE IN ANTI-RETROVIRAL TREATED HIV INFECTED PATIENTS. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2010;15(50):1-7. Available from: https://sid.ir/paper/53004/en

IEEE: Copy

A. RAMEZANI, R. HAMKAR, A. AGHAKHANI, SH. LORESTANI, M. BANIFAZL, H.H. TRUONG, W. MCFARLAND, M. FOROUGHI, A. ESLAMIFAR, and M. MOHRAZ, “SUBTYPE MUTATIONS AND RELATED DRUG-RESISTANCE IN ANTI-RETROVIRAL TREATED HIV INFECTED PATIENTS,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 15, no. 50, pp. 1–7, 2010, [Online]. Available: https://sid.ir/paper/53004/en

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