TREATMENT OF POSTSURGICAL FIBRINOUS MEMBRANE WITH RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR

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SIATIRI H.; BEHESHTNEZHAD A.H.; AMOUZADEH J.; SHAHHOSSEINI S.; FARAJI OSKOOYEE J.

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Journal: JOURNAL OF CURRENT OPHTHALMOLOGY Year:2004 | Volume:17 | Issue:2 Page(s): 83-88

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Title

TREATMENT OF POSTSURGICAL FIBRINOUS MEMBRANE WITH RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR

Author(s)

Keywords

FIBRINOUS MEMBRANEQ4

RECOMBINANT TISSUE PLASMINOGEN ACTIVATORQ4

Abstract

Purpose: The purpose of this study is to investigate the efficacy of RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR (r-tPA) in treatment of postsurgical FIBRINOUS MEMBRANE and to experience the special and relatively difficult process of preparing and preserving this drug.Patients and Methods: In a prospectivestudy, 5 eyes of 5 patients with thick fibrin membrane following anterior segment surgery received 20 μg r-tPA intracamerally through a paracentesis.Results: Complete fibrinolysis occurred 2-20 h after injection in 3 eyes without any complication or recurrence over the three months follow up. In one case with a thick fibrin membrane for 3 months, r-tPA injection failed. In one patient, the membrane disappeared completely during the first 24 h after injection, but recurred 1 week later due to underlying mild endophthalmitis.Conclusion: The authors believe that intraocular r-tPA is effective and relatively safe in the treatment of severe therapy-resistant cases of intracameral fibrin reaction, if given at appropriate time.

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APA: Copy

SIATIRI, H., BEHESHTNEZHAD, A.H., AMOUZADEH, J., SHAHHOSSEINI, S., & FARAJI OSKOOYEE, J.. (2004). TREATMENT OF POSTSURGICAL FIBRINOUS MEMBRANE WITH RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR. JOURNAL OF CURRENT OPHTHALMOLOGY, 17(2), 83-88. SID. https://sid.ir/paper/53115/en

Vancouver: Copy

SIATIRI H., BEHESHTNEZHAD A.H., AMOUZADEH J., SHAHHOSSEINI S., FARAJI OSKOOYEE J.. TREATMENT OF POSTSURGICAL FIBRINOUS MEMBRANE WITH RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR. JOURNAL OF CURRENT OPHTHALMOLOGY[Internet]. 2004;17(2):83-88. Available from: https://sid.ir/paper/53115/en

IEEE: Copy

H. SIATIRI, A.H. BEHESHTNEZHAD, J. AMOUZADEH, S. SHAHHOSSEINI, and J. FARAJI OSKOOYEE, “TREATMENT OF POSTSURGICAL FIBRINOUS MEMBRANE WITH RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR,” JOURNAL OF CURRENT OPHTHALMOLOGY, vol. 17, no. 2, pp. 83–88, 2004, [Online]. Available: https://sid.ir/paper/53115/en

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