INTRODUCTION OF NEW DERIVATIVES OF BIOTIN AND DTPA FOR LABELING OF ANTIBODIES WITH 111IN TO DETECT MALIGNANT TUMORS

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SHAHHOSSEINI S.; FARSHID FAR GH.R.; NAJAFI R.

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Journal: IRANIAN JOURNAL OF NUCLEAR MEDICINE Year:2002 | Volume:- | Issue:18 Page(s): 29-35

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Title

INTRODUCTION OF NEW DERIVATIVES OF BIOTIN AND DTPA FOR LABELING OF ANTIBODIES WITH 111IN TO DETECT MALIGNANT TUMORS

Author(s)

SHAHHOSSEINI S. | FARSHID FAR GH.R. | NAJAFI R. | Issue Writer Certificate

Keywords

MONOCLONAL ANTIBODY (MAB)

DIETHYLENTRIAMINEPANTAACETICACIDE (DTPA)

INDIUM-111 (¹¹¹IN)

FAST PERFORMANCE LIQUID CHROMATOGRAPHY (FPLC)

Abstract

Radiolabeled monoclonal antibodies, have created new innovations in diagnosis, research and therapy of disease in last 2 decades. One of the serious limitation of applications of radiolabeled antibodies in vivo is relatively low target to background activity. Various strategies have been proposed to solve this problem including pre-targeting methods that was suggested in 1989. Regarding importance of monoclonal antibodies and radioisotopes, based on pre-targeting strategy, we have introduced new derivative of Biotin and DTPA to decrease background activity. DTPA-bio and new derivative (DTPA-bio-10X) were labeled with ¹¹¹In, labeled compounds and injected through tail veins into Balb/c mice, and percent of injected dose per gram of blood (%ID/g of blood) was determined at 15, 30, 60, 120, 180, and 240 min after injection. Based on results,¹¹¹In-DTPA-bio rapidly cleared from serum, indicating molecular weight of label is increased causing delayed clearance from serum. Therefore, there is enough time for label to accumulate in the target tissues. With advent of second generation of monoclonal antibodies and antibody engineering, pretargeting methods have changed greatly. It seems that derivatives we introduced will have an important role in new pre-targeting methods

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APA: Copy

SHAHHOSSEINI, S., FARSHID FAR, GH.R., & NAJAFI, R.. (2002). INTRODUCTION OF NEW DERIVATIVES OF BIOTIN AND DTPA FOR LABELING OF ANTIBODIES WITH 111IN TO DETECT MALIGNANT TUMORS. IRANIAN JOURNAL OF NUCLEAR MEDICINE, -(18), 29-35. SID. https://sid.ir/paper/531548/en

Vancouver: Copy

SHAHHOSSEINI S., FARSHID FAR GH.R., NAJAFI R.. INTRODUCTION OF NEW DERIVATIVES OF BIOTIN AND DTPA FOR LABELING OF ANTIBODIES WITH 111IN TO DETECT MALIGNANT TUMORS. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2002;-(18):29-35. Available from: https://sid.ir/paper/531548/en

IEEE: Copy

S. SHAHHOSSEINI, GH.R. FARSHID FAR, and R. NAJAFI, “INTRODUCTION OF NEW DERIVATIVES OF BIOTIN AND DTPA FOR LABELING OF ANTIBODIES WITH 111IN TO DETECT MALIGNANT TUMORS,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. -, no. 18, pp. 29–35, 2002, [Online]. Available: https://sid.ir/paper/531548/en

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