EFFECTS OF ALLOPURINOL ON CHOLESTASIS-INDUCED RENAL INJURY

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KADKHODAEI M.; YOUSEFI Y.; MINAEI ZANGI M.B.; DEHPOUR A.R.

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Journal Paper

Paper Information

Journal: KOWSAR MEDICAL JOURNAL Year:2001 | Volume:6 | Issue:part 3 Page(s): 147-154

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Title

EFFECTS OF ALLOPURINOL ON CHOLESTASIS-INDUCED RENAL INJURY

Author(s)

KADKHODAEI M. | YOUSEFI Y. | MINAEI ZANGI M.B. | DEHPOUR A.R. | Issue Writer Certificate

Keywords

CHOLESTASIS

OXYGEN-DERIVED FREE RADICALS

ALLOPURINOL

RENAL FAILURE

Abstract

Several studies have suggested that CHOLESTASIS (bile-duct resection, obstructive jaundice) causes renal damage. In fact,renal failure is the most significant cause of morbidity and mortality in the cholestatic patients. In this study, the antioxidant drug, ALLOPURINOL as a xanthine oxidase .inhibitor was used (1 mg/ml in drinking water and 20 mg/kg Lp. one day before surgery) to evaluate the OFR involvement in CHOLESTASIS-induced renal damage. Three groups of rats, control (n=6); cholestatic with (n=10) and without (n=10) treatment were studied by light microscopy for renal histological changes. In this study the renal tubules in cholestatic rats, were highly damaged ten days after CHOLESTASIS. Necrosis was seen and tubular cast formation was frequent in the lumen of tubules. In the treated kidneys, there was some trend to improvement in renal morphology, namely less cellular vacuolation and tubular damage and less luminal debris. Since ALLOPURINOL improved histological changes in rat kidney, this study suggests OFR involvement in renal damage was induced by CHOLESTASIS.

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APA: Copy

KADKHODAEI, M., YOUSEFI, Y., MINAEI ZANGI, M.B., & DEHPOUR, A.R.. (2001). EFFECTS OF ALLOPURINOL ON CHOLESTASIS-INDUCED RENAL INJURY. KOWSAR MEDICAL JOURNAL, 6(part 3), 147-154. SID. https://sid.ir/paper/532116/en

Vancouver: Copy

KADKHODAEI M., YOUSEFI Y., MINAEI ZANGI M.B., DEHPOUR A.R.. EFFECTS OF ALLOPURINOL ON CHOLESTASIS-INDUCED RENAL INJURY. KOWSAR MEDICAL JOURNAL[Internet]. 2001;6(part 3):147-154. Available from: https://sid.ir/paper/532116/en

IEEE: Copy

M. KADKHODAEI, Y. YOUSEFI, M.B. MINAEI ZANGI, and A.R. DEHPOUR, “EFFECTS OF ALLOPURINOL ON CHOLESTASIS-INDUCED RENAL INJURY,” KOWSAR MEDICAL JOURNAL, vol. 6, no. part 3, pp. 147–154, 2001, [Online]. Available: https://sid.ir/paper/532116/en

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