THE EFFECTS OF LEAD AND ALUMINIUM ON THE NEURONAL EXCITABILITY AND BIOELECTRICAL CHARACTERISTICS OF F77 NEURON IN THE HELIX KPERSA

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ZAREEIAN P.; JANAHMADI M.; MOTAMEDI F.; FIROUZABADI M.

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Journal: KOWSAR MEDICAL JOURNAL Year:2001 | Volume:6 | Issue:part 1 Page(s): 29-40

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Title

THE EFFECTS OF LEAD AND ALUMINIUM ON THE NEURONAL EXCITABILITY AND BIOELECTRICAL CHARACTERISTICS OF F77 NEURON IN THE HELIX KPERSA

Author(s)

ZAREEIAN P. | JANAHMADI M. | MOTAMEDI F. | FIROUZABADI M. | Issue Writer Certificate

Keywords

CURRENT CLAMP

ACTION POTENTIAL

LEAD

ALUMINUM

HELIX ASPERSA

Abstract

The effects of Al+3 and Pb+2 were examined on the calcium spikes of HELIX ASPERSA F77 neuron, using two microelectrode CURRENT CLAMP technique. These results show that in the normal Ringer, the ACTION POTENTIAL is sodium-calcium dependent. The important role of calcium ions in the depolarizing phase of the ACTION POTENTIAL was observable as long duration ACTION POTENTIALs with a plateau, when Na + and K+ ions were eliminated and sodium-potassium channel blockers were used. Nifedipine (lµ,M), a specific L-type calcium channel blaker, decreased ACTION POTENTIAL duration (P < 0.01). Application of lead (0.6 and 3 µ,M) led to significant decrease in threshold and duration of action potential (P<0.05). The effects of LEAD were not dose dependent. ALUMINUM (150µM) at pH between 6.8 to 6.9, affected excitability and bioelectrical characteristics of F77 neurons. The resting membrane potential, firing threshold, peak, amplitude, duration and frequency of ACTION POTENTIALs were reduced significantly in the presence of aluminium. In summary, the results of this study demonstrate that LEAD and ALUMINUM exert at least a part of their neurotoxic actions by alterning the neuronal excitability and action potential characteristics.

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APA: Copy

ZAREEIAN, P., JANAHMADI, M., MOTAMEDI, F., & FIROUZABADI, M.. (2001). THE EFFECTS OF LEAD AND ALUMINIUM ON THE NEURONAL EXCITABILITY AND BIOELECTRICAL CHARACTERISTICS OF F77 NEURON IN THE HELIX KPERSA. KOWSAR MEDICAL JOURNAL, 6(part 1), 29-40. SID. https://sid.ir/paper/532141/en

Vancouver: Copy

ZAREEIAN P., JANAHMADI M., MOTAMEDI F., FIROUZABADI M.. THE EFFECTS OF LEAD AND ALUMINIUM ON THE NEURONAL EXCITABILITY AND BIOELECTRICAL CHARACTERISTICS OF F77 NEURON IN THE HELIX KPERSA. KOWSAR MEDICAL JOURNAL[Internet]. 2001;6(part 1):29-40. Available from: https://sid.ir/paper/532141/en

IEEE: Copy

P. ZAREEIAN, M. JANAHMADI, F. MOTAMEDI, and M. FIROUZABADI, “THE EFFECTS OF LEAD AND ALUMINIUM ON THE NEURONAL EXCITABILITY AND BIOELECTRICAL CHARACTERISTICS OF F77 NEURON IN THE HELIX KPERSA,” KOWSAR MEDICAL JOURNAL, vol. 6, no. part 1, pp. 29–40, 2001, [Online]. Available: https://sid.ir/paper/532141/en

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