CISAPRIDE AND RISK OF CARDIAC COMPLICATIONS IN INFANTS WITH GASTROESOPHAGEAL REFLUX

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MOJTAHEDZADEH S.; IMSNZADEH F.; KHODADAD A.; KACHARIAN A.; SABERI F.

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Journal: Researcher Bulletin of Medical Sciences Year:2001 | Volume:6 | Issue:3 (23) Page(s): 249-252

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Title

CISAPRIDE AND RISK OF CARDIAC COMPLICATIONS IN INFANTS WITH GASTROESOPHAGEAL REFLUX

Author(s)

Keywords

GASTROESOPHAGEAL REFLUX

CISAPRIDE

CARDIAC COMPLICATIONS

ECG CHANGES

PROLONGED QT

Abstract

Background: GASTROESOPHAGEAL REFLUX is among the most common GI disorders during infancy that has known complications in case of leaving untreated. CISAPRIDE is an effective drug but controversies about its CARDIAC COMPLICATIONS and genetic predisposing factors still exist. So the present study was designed with the aim of determining the CARDIAC COMPLICATIONS of CISAPRIDE in infants with GER referring to a private clinic in Tehran, 2000. Materials and methods: The before and after clinical trial strategy of this research was achieved over 54 infants with normal ECG. CISAPRIDE was given in dose of 1 mg/kg/day, and then 24-72 hours later the second ECG was observed. Cardiac complication was defined as PROLONGED QTc intervals (>450 ms). Statistical analysis was performed using Mcnemar and paired Hest. Results: 54 infants, including 3] males and 23 females, with mean age of 3.5 months had entered our study. Cardiac complication was reported in 2 (3.7%) infants (N.S). QTc intervals were increased from 403±35 to 420±34.5 ms (p<0.001). Other indices such as pulse rate, PR and QRS intervals were intact. Conclusion: GASTROESOPHAGEAL REFLUX is a common disorder and drug side effects are usually seen, so CISAPRIDE could be safely prescribed according to the Y van recommendation.

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APA: Copy

MOJTAHEDZADEH, S., IMSNZADEH, F., KHODADAD, A., KACHARIAN, A., & SABERI, F.. (2001). CISAPRIDE AND RISK OF CARDIAC COMPLICATIONS IN INFANTS WITH GASTROESOPHAGEAL REFLUX. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 6(3 (23)), 249-252. SID. https://sid.ir/paper/532998/en

Vancouver: Copy

MOJTAHEDZADEH S., IMSNZADEH F., KHODADAD A., KACHARIAN A., SABERI F.. CISAPRIDE AND RISK OF CARDIAC COMPLICATIONS IN INFANTS WITH GASTROESOPHAGEAL REFLUX. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2001;6(3 (23)):249-252. Available from: https://sid.ir/paper/532998/en

IEEE: Copy

S. MOJTAHEDZADEH, F. IMSNZADEH, A. KHODADAD, A. KACHARIAN, and F. SABERI, “CISAPRIDE AND RISK OF CARDIAC COMPLICATIONS IN INFANTS WITH GASTROESOPHAGEAL REFLUX,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 6, no. 3 (23), pp. 249–252, 2001, [Online]. Available: https://sid.ir/paper/532998/en

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