THE PROTECTIVE ROLE OF CAPTOPRIL IN RENAL DAMAGE AFTER RENAL ISCHEMIA AND REPERFUSION AND ROLE OF ATP REPENENT POTASSIUM CHANNELS (KATP)

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REZAEI SALIM M.; SADR S.SH.A.D.; GOLCHIN M.; PAZOUKI TOROUDI H.R.

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Journal: Iranian Journal of Forensic Medicine Year:2002 | Volume:8 | Issue:27 Page(s): 28-33

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Title

THE PROTECTIVE ROLE OF CAPTOPRIL IN RENAL DAMAGE AFTER RENAL ISCHEMIA AND REPERFUSION AND ROLE OF ATP REPENENT POTASSIUM CHANNELS (KATP)

Author(s)

REZAEI SALIM M. | SADR S.SH.A.D. | GOLCHIN M. | PAZOUKI TOROUDI H.R. | Issue Writer Certificate

Keywords

ISCHEMIAQ4

REPERFUSIONQ4

ANGIOTENSIN INHIBITORQ4

ATP DEPENDENT POTASSIUM CHANNELS (KATP)Q4

Abstract

Background: Renal damage after renal ISCHEMIA and REPERFUSION has been studied frequently and it is known that the ACE inhibitors have a pronounced effect on its prevention. Also there are many reports about the effect of KATP channels on heart ISCHEMIA and REPERFUSION to the heart. In regard to above research, in this study the effect of blockers on potassium channels related to ATP was compared to the effect of captopril in kidneys which were ischemic and then reperfused were studied.Methods: In this study, Glibenclaimide (1,5,25 mg/kg) and Captopril (5mg/kg) were administred to rats. Then they anesthesized with ketamin (50 mg/kg) and xylocaine (10 mg/kg), their flanks were opened. The left renal vein was obstructed for 30 minutes, then opened for 2 hours, afterward, the rats were killed and their left and right kidney were studied microscopically.Results: The results showed that captopril can decrease ISCHEMIA damage, but Glibenclamide had not such effect.Conclusion: The effect of captopril is not related to KATP channels and is probably due to oxygen free radicals and protein kinase C.

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APA: Copy

REZAEI SALIM, M., SADR, S.SH.A.D., GOLCHIN, M., & PAZOUKI TOROUDI, H.R.. (2002). THE PROTECTIVE ROLE OF CAPTOPRIL IN RENAL DAMAGE AFTER RENAL ISCHEMIA AND REPERFUSION AND ROLE OF ATP REPENENT POTASSIUM CHANNELS (KATP). SCIENTIFIC JOURNAL OF FORENSIC MEDICINE, 8(27), 28-33. SID. https://sid.ir/paper/53524/en

Vancouver: Copy

REZAEI SALIM M., SADR S.SH.A.D., GOLCHIN M., PAZOUKI TOROUDI H.R.. THE PROTECTIVE ROLE OF CAPTOPRIL IN RENAL DAMAGE AFTER RENAL ISCHEMIA AND REPERFUSION AND ROLE OF ATP REPENENT POTASSIUM CHANNELS (KATP). SCIENTIFIC JOURNAL OF FORENSIC MEDICINE[Internet]. 2002;8(27):28-33. Available from: https://sid.ir/paper/53524/en

IEEE: Copy

M. REZAEI SALIM, S.SH.A.D. SADR, M. GOLCHIN, and H.R. PAZOUKI TOROUDI, “THE PROTECTIVE ROLE OF CAPTOPRIL IN RENAL DAMAGE AFTER RENAL ISCHEMIA AND REPERFUSION AND ROLE OF ATP REPENENT POTASSIUM CHANNELS (KATP),” SCIENTIFIC JOURNAL OF FORENSIC MEDICINE, vol. 8, no. 27, pp. 28–33, 2002, [Online]. Available: https://sid.ir/paper/53524/en

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