ULTRASTRUCTURAL STUDY OF COMBINED THERAPY EFFECT OF LOSARTAN AND OCTREOTIDE ON INHIBITION OF GLOMERULAR EPITHELIAL CHANGES IN UNINEPHRECTOMIZED DIABETIC RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TAVAFI M.; DEZFOULIAN A.; SHAMS A.; TABATABAEI P.; TAVAKOLI A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Arak University Medical Sciences Year:2005 | Volume:8 | Issue:2 (31) Page(s): 32-44

Download Full-Text

View:

246

Download:

Cites:

Information Journal Paper

Title

ULTRASTRUCTURAL STUDY OF COMBINED THERAPY EFFECT OF LOSARTAN AND OCTREOTIDE ON INHIBITION OF GLOMERULAR EPITHELIAL CHANGES IN UNINEPHRECTOMIZED DIABETIC RATS

Author(s)

Keywords

LOSARTAN

OCTREOTIDE

GBM

PODOCYTE PEDICLES FUSION

ULTRASTRUCTURAL STUDY

DIABETTES

Abstract

Introduction: In diabetes mellitus the increase of AgII (Angiotensin II), IGF1 (insulin like growth factor-1) and growth hormone induce kidney lesions especially changes in content and thickness of GBM and widening and fusion of podocyte pedicles. In this research for the first time the combination of LOSARTAN (AT1 receptor blocker) and OCTREOTIDE (Somatostatin analogue) were used in order to prevent glomerular epithelial lesions.Materials & methods: In this experimental study 15 male rats (2 months age) were uninephrectomised from left flank and divided in 5 groups (3 per group). 7 days later diabetes was induced in 2th, 3th, 4th and 5th group by Alloxan (120 mg/kg) subcutaneously. 5 days after diabetes induction, the third group received LOSARTAN (5mg/kg/day) orally, 4th group Octretide (10 ûg/day) subcutaneously and 5th group both two drugs with the mentioned doses for 8 weeks. The 2th group was served as diabetic non treatment group. Kidneys of all groups were fixed by perfusion technique. After second fixation of 1 mm3 cortex parts in Osmium Tetroxide, they were processed in TAAB812 resin for embedding. Thin sections (600 nm thickness) were prepared and investigated by transmission electron microscope qualitatively.Results: LOSARTAN inhibited fusion and thickening of podocyte pedic1es but in some cases couldn't maintain the 3 layer form of GBM. OCTREOTIDE had little effect on inhibition of fusion and thickening of podocyte pedicles and no effect in 3 layer form maintaining of GBM.Combined therapy inhibited fusion and thickening of podocyte pedic1es and maintained 3 layer form of GBM but in some cases the lamina rara near endothelium was not seen.Conclusion: OCTREOTIDE have little effect on prevention of glomerular epithelium lesions. However LOSARTAN could prevent glomerular epithelium lesions well, but combined drug therapy showed better results comparing LOSARTAN.

Cites

No record.

References

No record.

Cite

APA: Copy

TAVAFI, M., DEZFOULIAN, A., SHAMS, A., TABATABAEI, P., & TAVAKOLI, A.. (2005). ULTRASTRUCTURAL STUDY OF COMBINED THERAPY EFFECT OF LOSARTAN AND OCTREOTIDE ON INHIBITION OF GLOMERULAR EPITHELIAL CHANGES IN UNINEPHRECTOMIZED DIABETIC RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 8(2 (31)), 32-44. SID. https://sid.ir/paper/535522/en

Vancouver: Copy

TAVAFI M., DEZFOULIAN A., SHAMS A., TABATABAEI P., TAVAKOLI A.. ULTRASTRUCTURAL STUDY OF COMBINED THERAPY EFFECT OF LOSARTAN AND OCTREOTIDE ON INHIBITION OF GLOMERULAR EPITHELIAL CHANGES IN UNINEPHRECTOMIZED DIABETIC RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2005;8(2 (31)):32-44. Available from: https://sid.ir/paper/535522/en

IEEE: Copy

M. TAVAFI, A. DEZFOULIAN, A. SHAMS, P. TABATABAEI, and A. TAVAKOLI, “ULTRASTRUCTURAL STUDY OF COMBINED THERAPY EFFECT OF LOSARTAN AND OCTREOTIDE ON INHIBITION OF GLOMERULAR EPITHELIAL CHANGES IN UNINEPHRECTOMIZED DIABETIC RATS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 8, no. 2 (31), pp. 32–44, 2005, [Online]. Available: https://sid.ir/paper/535522/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops