FREQUENCY OF NEPHROPATHY AND ITS RELATION TO METABOLIC CONTROL IN PATIENTS WITH DIABETES MELLITUS

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RAZAGHI AZAR MARYAM; FARAHNAK Z.

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Journal: ARYA Atherosclerosis Year:2008 | Volume:3 | Issue:4 Page(s): 219-222

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Title

FREQUENCY OF NEPHROPATHY AND ITS RELATION TO METABOLIC CONTROL IN PATIENTS WITH DIABETES MELLITUS

Author(s)

RAZAGHI AZAR MARYAM | FARAHNAK Z. | Issue Writer Certificate

Keywords

DIABETIC NEPHROPATHY

ALBUMINURIA

END-STAGE RENAL DISEASE

Abstract

INTRODUCTION: DIABETIC NEPHROPATHY is a serious complication of both type 1 and type 2 diabetes, and unless arrested, leads to END-STAGE RENAL DISEASE. The aim of this study was to find the prevalence of kidney dysfunction in patients with diabetes mellitus and to determine its correlation with metabolic control.METHODS: We randomly selected 1203 cases with diabetes mellitus presenting to the Institute of Endocrinology and Metabolism. Urinary protein and creatinine were determined in a sample of 24-hour urine collection by the enzymatic methods and spot urine dipstick blood urea nitrogen, serum creatinine, HbA1c and fasting blood glucose were assessed.RESULTS: In this study, 1203 patients (438 patients with type 1 diabetes mellitus [T1DM] and 777 with type 2 diabetes mellitus [T2DM]) were randomly selected. They consisted of 512 females and 721 males. Mean ± SD (standard deviation) of HbA1c was 7.9±3.4 in T1DM and 7.4±3.5 in T2DM. Based on HbA1c levels, good control was detected in 50.2% of patients, fair control in 20.4% and bad control in 29.4%. Of 1022 patients who were evaluated for proteinuria, 201 (19.7%) had ALBUMINURIA or clinical proteinuria. Of 931 patients, 19% had high levels of blood urea nitrogen and serum creatinine. END-STAGE RENAL DISEASE (ESRD) was seen in 10 (0.8%) of all the cases. A statistically significant positive correlation was found between duration of DM, serum creatinine and 24-hour urinary protein (P< 0.001).CONCLUSION: We found a high prevalence of clinical proteinuria in diabetic patients. Duration of diabetes and poor metabolic control were identified as a strong predictors of kidney damage in patients with diabetes.

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APA: Copy

RAZAGHI AZAR, MARYAM, & FARAHNAK, Z.. (2008). FREQUENCY OF NEPHROPATHY AND ITS RELATION TO METABOLIC CONTROL IN PATIENTS WITH DIABETES MELLITUS. ARYA ATHEROSCLEROSIS, 3(4), 219-222. SID. https://sid.ir/paper/537691/en

Vancouver: Copy

RAZAGHI AZAR MARYAM, FARAHNAK Z.. FREQUENCY OF NEPHROPATHY AND ITS RELATION TO METABOLIC CONTROL IN PATIENTS WITH DIABETES MELLITUS. ARYA ATHEROSCLEROSIS[Internet]. 2008;3(4):219-222. Available from: https://sid.ir/paper/537691/en

IEEE: Copy

MARYAM RAZAGHI AZAR, and Z. FARAHNAK, “FREQUENCY OF NEPHROPATHY AND ITS RELATION TO METABOLIC CONTROL IN PATIENTS WITH DIABETES MELLITUS,” ARYA ATHEROSCLEROSIS, vol. 3, no. 4, pp. 219–222, 2008, [Online]. Available: https://sid.ir/paper/537691/en

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