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Information Journal Paper

Title

THE PRO-ABSORPTIVE EFFECT OF ACANTHOPHYLLUM SQUARROSUM ON INTRANASAL INSULIN DELIVERY AND ITS EFFECT ON BLOOD GLUCOSE IN RATS

Pages

  17-24

Abstract

 Objective: To compare the effect on INSULIN absorption intra-nasally of ACANTHOPHYLLUM SQUARROSUM (ASQ) compared with ACANTHOPHYLLUM SAPONARIA (ASA) and SODIUM CHOLATE (NAC), which have proven pro-absorptive effects. Methods: The formulation used in this study contained 2IU INSULIN (per rat), 1% carboxymethylcellulose (CMC) and a pro-absorptive agent at the same concentration. We assessed the hypoglycaemic effect of each formulation in 5 rats in the fasting state. Results: There was no significant difference in the pro-absorptive effects of ASQ, ASA, and NAC. Blood glucose levels 2 hours after administration of INSULIN, given as a percentage of baseline glucose concentration, were as follows for the three formulations used: ASQ: 36.78±11.06%, ASA: 27.46±2.39%, and NAC: 39.94±14.93%. Conclusion: ACANTHOPHYLLUM SQUARROSUM has a significant pro-absorptive effect, comparable to that to ACANTHOPHYLLUM SAPONARIA.

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    APA: Copy

    SAJADI, S.A., HOSSEINZADEH, H., & MOHAJERI, S.A.. (2003). THE PRO-ABSORPTIVE EFFECT OF ACANTHOPHYLLUM SQUARROSUM ON INTRANASAL INSULIN DELIVERY AND ITS EFFECT ON BLOOD GLUCOSE IN RATS. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 2(1), 17-24. SID. https://sid.ir/paper/53864/en

    Vancouver: Copy

    SAJADI S.A., HOSSEINZADEH H., MOHAJERI S.A.. THE PRO-ABSORPTIVE EFFECT OF ACANTHOPHYLLUM SQUARROSUM ON INTRANASAL INSULIN DELIVERY AND ITS EFFECT ON BLOOD GLUCOSE IN RATS. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2003;2(1):17-24. Available from: https://sid.ir/paper/53864/en

    IEEE: Copy

    S.A. SAJADI, H. HOSSEINZADEH, and S.A. MOHAJERI, “THE PRO-ABSORPTIVE EFFECT OF ACANTHOPHYLLUM SQUARROSUM ON INTRANASAL INSULIN DELIVERY AND ITS EFFECT ON BLOOD GLUCOSE IN RATS,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 2, no. 1, pp. 17–24, 2003, [Online]. Available: https://sid.ir/paper/53864/en

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