EFFECT OF INSULIN ON LOCAL AND TISSUE ACE ACTIVITY IN DIABETIC RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHARIFI A.M.; MOUSAVI S.H.; ARDESHIR LARIJANI MOHAMMAD BAGHER

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Diabetes and Metabolism Year:2004 | Volume:3 | Issue:2 Page(s): 195-200

Download Full-Text

Persian Verion

View:

1,168

Download:

Cites:

Information Journal Paper

Title

EFFECT OF INSULIN ON LOCAL AND TISSUE ACE ACTIVITY IN DIABETIC RATS

Author(s)

SHARIFI A.M. | MOUSAVI S.H. | ARDESHIR LARIJANI MOHAMMAD BAGHER | Issue Writer Certificate

Keywords

INSULINQ3

SYSTOLIC BLOOD PRESSUREQ4

ACE ACTIVITYQ4

STZ INDUCED DIABETESQ4

Abstract

Background: The precise mechanisms of vascular diseases in INSULIN dependent diabetes mellitus (IDDM) are not clearly understood. There are evidences of alteration in mechanisms involved in regulating vascular tone including increased ACE ACTIVITY in some tissues. To investigate the effect of INSULIN treatment on these changes this study was performed. Methods: Three groups of 8 male Sprauge Dawely rats including control (C) and two diabetic groups (D, IT) were used in this study. Diabetes was induced by injection of 60 mg/kg STZ ip. After induction of diabetes IT group were treated with INSULIN (10 units/kg/day s.c.) for four weeks. The control group and the untreated diabetic group were treated with the same amount of Saline and for the same time. ACE ACTIVITY was determined by HPLC method.Results: 4 weeks after induction of diabetes, SBP and ACE ACTIVITY in serum, lung, heart and aorta increased in D group compared to control rats. INSULIN treatment reversed these changes to normal values in IT group.Conclusion: It is concluded that increased ACE ACTIVITY could contribute to the development of diabetic vasculopathy and ACE reducing activity of INSULIN may be partially involved in decrease of cardiovascular complications in diabetes.

Cites

No record.

References

No record.

Cite

APA: Copy

SHARIFI, A.M., MOUSAVI, S.H., & ARDESHIR LARIJANI, MOHAMMAD BAGHER. (2004). EFFECT OF INSULIN ON LOCAL AND TISSUE ACE ACTIVITY IN DIABETIC RATS. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 3(2), 195-200. SID. https://sid.ir/paper/53874/en

Vancouver: Copy

SHARIFI A.M., MOUSAVI S.H., ARDESHIR LARIJANI MOHAMMAD BAGHER. EFFECT OF INSULIN ON LOCAL AND TISSUE ACE ACTIVITY IN DIABETIC RATS. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2004;3(2):195-200. Available from: https://sid.ir/paper/53874/en

IEEE: Copy

A.M. SHARIFI, S.H. MOUSAVI, and MOHAMMAD BAGHER ARDESHIR LARIJANI, “EFFECT OF INSULIN ON LOCAL AND TISSUE ACE ACTIVITY IN DIABETIC RATS,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 3, no. 2, pp. 195–200, 2004, [Online]. Available: https://sid.ir/paper/53874/en

Related Journal Papers