EFFECT OF OPIUM ADDICTION ON LIPID PROFILE AND ATHEROSCLEROSIS AMONG NORMAL AND HYPERCHOLESTEROLEMIC RABBITS

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MOHAMMADI GHOLAM ABAS; DARABI AMIN MARYAM; SABET JAHROMI M.J.; SHEYBANI H.; NASRI M.; MALEKPOUR AFSHAR R.

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Journal: Iranian Journal of Diabetes and Metabolism Year:2007 | Volume:6 | Issue:4 Page(s): 327-335

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Title

EFFECT OF OPIUM ADDICTION ON LIPID PROFILE AND ATHEROSCLEROSIS AMONG NORMAL AND HYPERCHOLESTEROLEMIC RABBITS

Author(s)

Keywords

ATHEROSCLEROSISQ3

ADDICTIONQ3

OPIUMQ3

CHOLESTEROLQ3

Abstract

Background: ATHEROSCLEROSIS is the leading cause of mortality in the developed and some developing countries. Some people believe that OPIUM abuse has beneficial effects for reducing blood lipids and ATHEROSCLEROSIS prevention. In this study, the effect of oral OPIUM ADDICTION on lipid profile and atherogenesis in normal and hypercholesterolemic rabbits was studied.Methods: Thirty two male Newzeland White rabbits were used in this study. They were divided into four groups including control, hypercholesterolemic, addicted, and hypercholesterolemic addicted and were studied for three months. The blood samples were obtained and lipid profile was determined at the beginning of the study and at the end of every month thereafter. After 90 days aorta was removed to assess for lesion formation.Results: The levels of CHOLESTEROL, triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), and atherogenic index (total CHOLESTEROL/HDL-C) in the hypercholesterolemic and hypercholesterolemic addicted rabbits were increased significantly (P<0.001). These increases in lipids and aorta lesion areas were higher in hypercholesterolemic addicted group than hypercholesterolemic group.Conclusion: These findings suggest that oral OPIUM abuse affects CHOLESTEROL metabolism and depending on the dietary condition can have an aggravating effect on ATHEROSCLEROSIS. The protective effect of mrphine on cardiac disease is not probably through the modulation of lipid metabolism.

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References

THE CAUSES OF DELAYING HOSPITAL ADMISSION OF PATIENTS WITH ACUTE MYOCARDIAL INFARCTION TO THE HOSPITALS IN KERMAN CITY(2000)

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APA: Copy

MOHAMMADI, GHOLAM ABAS, DARABI AMIN, MARYAM, SABET JAHROMI, M.J., SHEYBANI, H., NASRI, M., & MALEKPOUR AFSHAR, R.. (2007). EFFECT OF OPIUM ADDICTION ON LIPID PROFILE AND ATHEROSCLEROSIS AMONG NORMAL AND HYPERCHOLESTEROLEMIC RABBITS. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 6(4), 327-335. SID. https://sid.ir/paper/53889/en

Vancouver: Copy

MOHAMMADI GHOLAM ABAS, DARABI AMIN MARYAM, SABET JAHROMI M.J., SHEYBANI H., NASRI M., MALEKPOUR AFSHAR R.. EFFECT OF OPIUM ADDICTION ON LIPID PROFILE AND ATHEROSCLEROSIS AMONG NORMAL AND HYPERCHOLESTEROLEMIC RABBITS. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2007;6(4):327-335. Available from: https://sid.ir/paper/53889/en

IEEE: Copy

GHOLAM ABAS MOHAMMADI, MARYAM DARABI AMIN, M.J. SABET JAHROMI, H. SHEYBANI, M. NASRI, and R. MALEKPOUR AFSHAR, “EFFECT OF OPIUM ADDICTION ON LIPID PROFILE AND ATHEROSCLEROSIS AMONG NORMAL AND HYPERCHOLESTEROLEMIC RABBITS,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 6, no. 4, pp. 327–335, 2007, [Online]. Available: https://sid.ir/paper/53889/en

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