THE IMPACT OF B-GROUP VITAMINS AND ANTIOXIDANTS ON SERUM LEVELS OF APOLIPOPROTEIN A1 AND B IN TYPE 2 DIABETES

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YAVARI P.; SIASI F.; CHAMARI M.; KESHAVARZ A.; JALALI M.; MOHAMMAD K.; ARDESHIR LARIJANI MOHAMMAD BAGHER

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Journal: Iranian Journal of Diabetes and Metabolism Year:2005 | Volume:5 | Issue:1 Page(s): 25-34

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Title

THE IMPACT OF B-GROUP VITAMINS AND ANTIOXIDANTS ON SERUM LEVELS OF APOLIPOPROTEIN A1 AND B IN TYPE 2 DIABETES

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Keywords

DIABETESQ2

B-GROUP VITAMINSQ4

VITAMIN EQ3

VITAMIN CQ3

APOLIPOPROTEIN A1Q4

APOLIPOPROTEIN BQ4

Abstract

Background: Lipoprotein abnormalities have been identified among the several risk factors that could account for increases the risk of CVD in DIABETES. Abnormal status of B-group and antioxidant vitamins in DIABETES may illustrate the benefits of these vitamins supplementation on modification of lipid profiles.Methods: As a randomized double blind placebo controlled clinical trial, 110 type 2 diabetic patients were randomly assigned to one of the five treatment groups and received one of the following supplements per day for a period of 2 months: 1) B-GROUP VITAMINS including B2 (10 mg), B6 (10mg), B12 (200μg) and Folate (1000μg); 2) B-GROUP VITAMINS and VITAMIN E (100mg); 3) B-GROUP VITAMINS and VITAMIN C (200mg); 4) B-GROUP VITAMINS, vitamins E (100mg) and C (200mg) and 5) placebo. Fasting blood samples at the beginning and at the end of 2 months trial were collected and analyzed for cholesterol, triglyceride, apolipoproteins A1 and B (apo A1 & B), VITAMIN E, folate, vitamin B12 in serum and VITAMIN C in whole blood. Differences in baselines models. Covariates and changes in variables during study were adjusted by analysis of covariance using general linear.Results: No significant changes were found in mean serum apolipoproteins levels after 2 months of supplementation. VITAMIN E variation showed significant positive correlation with variation in apo A1 (P=0.003) and apo B (P<0.001). In multiple regression analysis, serum VITAMIN E levels were an independent and important predictor of serum apoA1 and B levels (P=0.002 and P<0.001, respectively). Serum vitamin B12 variation was important predictor of serum apo B levels (P<0.05).Conclusion: Serum VITAMIN E level is a good predictor of serum apo A1 and B levels. Further increases in dose of vitamin supplements and intervention period are recommended for obtaining the desirable modifications.

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APA: Copy

YAVARI, P., SIASI, F., CHAMARI, M., KESHAVARZ, A., JALALI, M., MOHAMMAD, K., & ARDESHIR LARIJANI, MOHAMMAD BAGHER. (2005). THE IMPACT OF B-GROUP VITAMINS AND ANTIOXIDANTS ON SERUM LEVELS OF APOLIPOPROTEIN A1 AND B IN TYPE 2 DIABETES. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 5(1), 25-34. SID. https://sid.ir/paper/53898/en

Vancouver: Copy

YAVARI P., SIASI F., CHAMARI M., KESHAVARZ A., JALALI M., MOHAMMAD K., ARDESHIR LARIJANI MOHAMMAD BAGHER. THE IMPACT OF B-GROUP VITAMINS AND ANTIOXIDANTS ON SERUM LEVELS OF APOLIPOPROTEIN A1 AND B IN TYPE 2 DIABETES. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2005;5(1):25-34. Available from: https://sid.ir/paper/53898/en

IEEE: Copy

P. YAVARI, F. SIASI, M. CHAMARI, A. KESHAVARZ, M. JALALI, K. MOHAMMAD, and MOHAMMAD BAGHER ARDESHIR LARIJANI, “THE IMPACT OF B-GROUP VITAMINS AND ANTIOXIDANTS ON SERUM LEVELS OF APOLIPOPROTEIN A1 AND B IN TYPE 2 DIABETES,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 5, no. 1, pp. 25–34, 2005, [Online]. Available: https://sid.ir/paper/53898/en

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