ANTINOCICEPTIVE EFFECT OF BACLOFEN IN ALLOXAN-INDUCED DIABETIC MICE

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HOSSEINZADEH H.; ILAMI F.

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Paper Information

Journal: Iranian Journal of Diabetes and Metabolism Year:2002 | Volume:1 | Issue:1 Page(s): 53-57

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Information Journal Paper

Title

ANTINOCICEPTIVE EFFECT OF BACLOFEN IN ALLOXAN-INDUCED DIABETIC MICE

Author(s)

HOSSEINZADEH H. | ILAMI F. | Issue Writer Certificate

Keywords

BACLOFENQ4

HYPERGLYCEMIAQ3

ANTINOCICEPTIVE ACTIVITYQ4

GABAQ4

MORPHINEQ3

Abstract

Objective: To evaluate the effect of HYPERGLYCEMIA on the ANTINOCICEPTIVE ACTIVITY of BACLOFEN, a GABAB agonist, in mice. Methods: We examined the antinociceptive effect of BACLOFEN (2.5-7.5mg/kg injected intraperitoneally) in alloxan-induced mice using the hot-plate and tail-flick tests, both thermal tests. Results: BACLOFEN proquced a dose-dependent inhibition of hot-plate response in both normoglycemic and diabetic mice. The ANTINOCICEPTIVE ACTIVITY of BACLOFEN was slightly reduced in diabetic mice. In comparison, the ANTINOCICEPTIVE ACTIVITY of MORPHINE (10mg/kg), used as control, was significantly reduced in diabetic mice. Conclusion: Our results show that HYPERGLYCEMIA reduces the antinociceptive action of BACLOFEN less than it does that of MORPHINE.

Cites

ANIMAL MODELS OF DIABETES

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APA: Copy

HOSSEINZADEH, H., & ILAMI, F.. (2002). ANTINOCICEPTIVE EFFECT OF BACLOFEN IN ALLOXAN-INDUCED DIABETIC MICE . JOURNAL OF DIABETES AND METABOLIC DISORDERS, 1(1), 53-57. SID. https://sid.ir/paper/54022/en

Vancouver: Copy

HOSSEINZADEH H., ILAMI F.. ANTINOCICEPTIVE EFFECT OF BACLOFEN IN ALLOXAN-INDUCED DIABETIC MICE . JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2002;1(1):53-57. Available from: https://sid.ir/paper/54022/en

IEEE: Copy

H. HOSSEINZADEH, and F. ILAMI, “ANTINOCICEPTIVE EFFECT OF BACLOFEN IN ALLOXAN-INDUCED DIABETIC MICE ,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 1, no. 1, pp. 53–57, 2002, [Online]. Available: https://sid.ir/paper/54022/en

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