THE EFFECT OF CONTINUED DIABETES ON THE FORMALIN- INDUCED PAIN AND BACLOFEN ANALGESIA IN RAT

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NOUSHINFAR E.

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Journal: Researcher Bulletin of Medical Sciences Year:2003 | Volume:8 | Issue:2 (32) Page(s): 121-126

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Title

THE EFFECT OF CONTINUED DIABETES ON THE FORMALIN- INDUCED PAIN AND BACLOFEN ANALGESIA IN RAT

Author(s)

NOUSHINFAR E. | Issue Writer Certificate

Keywords

DIABETIC PAINFUL NEUROPATHYQ4

BACLOFENQ4

FORMALIN TESTQ3

Abstract

Background: Painful neuropathy is one of the side effects of diabetes mellitus, the treatment and etiology of which is still unknown. With respect to the importance of pain management, the present study was conducted to determine the effect of continued diabetes on the formalin-induced pain and BACLOFEN analgesia in Rat. Moreover effect of BACLOFEN as a non opiate, analgesic drug on the increased pains in the quiescent phase as the model of diabetic pain was investigated.Materials and methods: Seventy rats were included in this experimental study. The first group was assigned to control (injection normal saline) and diabetic (injection aloxan 100 mg/kg) which were tested, following the observation of the routines signals of diabetes, after one to four weeks from the beginning of diabetes, the second group was divided to a new control and diabetic group and before performing FORMALIN TEST, they received BACLOFEN (10mg/kg). The third group was divided to two diabetic groups that received BACLOFEN and normal saline and then the pain of the quiescent phase was compared between them.Results: The results indicated that diabetes increases formalin-induced pain (P<0.05) and remained with continued diabetes. It also indicated that diabetes established increased pain in the quiescent phase (P<0.05). Diabetes had no ii1fluence on the BACLOFEN analgesic effect, on the first phase of FORMALIN TEST and increased it on the second phase and also BACLOFEN could quiet the increased pain in quiescent phase (P<0.05).Conclusion: Diabetes mellitus could increase the formalin-induced pain in the first and second phases and also during the quiescent phase, via changes in the central and peripheral pathways. BACLOFEN could eliminate increased pain of quiescent phase, thus, we strongly recommend BACLOFEN as an effective drug to comfort painful diabetic neuropathy.

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APA: Copy

NOUSHINFAR, E.. (2003). THE EFFECT OF CONTINUED DIABETES ON THE FORMALIN- INDUCED PAIN AND BACLOFEN ANALGESIA IN RAT. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 8(2 (32)), 121-126. SID. https://sid.ir/paper/18377/en

Vancouver: Copy

NOUSHINFAR E.. THE EFFECT OF CONTINUED DIABETES ON THE FORMALIN- INDUCED PAIN AND BACLOFEN ANALGESIA IN RAT. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2003;8(2 (32)):121-126. Available from: https://sid.ir/paper/18377/en

IEEE: Copy

E. NOUSHINFAR, “THE EFFECT OF CONTINUED DIABETES ON THE FORMALIN- INDUCED PAIN AND BACLOFEN ANALGESIA IN RAT,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 8, no. 2 (32), pp. 121–126, 2003, [Online]. Available: https://sid.ir/paper/18377/en

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