ASSESSMENT OF THE RELATIONSHIP BETWEEN -1562C>T ALLELE OF MMP9 GENE PROMOTER WITH DIABETIC FOOT ULCER IN TYPE 2 DIABETIC PATIENTS REFERRED TO THE CLINIC OF DIABETES AND METABOLIC DISEASES

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SHAFIEE SAHAR; RAZ ABBASALI; ADIBI NEDA; MANSOURI MASOOMEH; ANNABESTANI ZOHREH; MIRZAEEZADEH ZAHRA; HASHEMI MEHRDAD; OMIDFAR KOBRA

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Journal: Iranian Journal of Diabetes and Metabolism Year:2017 | Volume:17 | Issue:1 Page(s): 49-56

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Title

ASSESSMENT OF THE RELATIONSHIP BETWEEN -1562C>T ALLELE OF MMP9 GENE PROMOTER WITH DIABETIC FOOT ULCER IN TYPE 2 DIABETIC PATIENTS REFERRED TO THE CLINIC OF DIABETES AND METABOLIC DISEASES

Author(s)

Keywords

TYPE 2 DIABETESQ1

DIABETIC FOOT ULCERQ2

MATRIX MATALLOPROTEINS-9 (MMP-9)Q1

BIOMARKERQ1

POLYMORPHISM -1562 C>TQ1

Abstract

Background: TYPE 2 DIABETES is the most common type of diabetes, and a complex endocrine metabolic disorder that one of its main complications is DIABETIC FOOT ULCERs. Matrix metalloproteinases (MMPs) are one of the key enzymes in the reconstruction of extracellular matrix which have proteolytic activity. The aim of this research is based on evaluating relationship between -1562 C>T allele at MMP-9 gene promoter with DIABETIC FOOT ULCER in type II diabetic patients. If such correlation proves, it can be used as a prognostic BIOMARKER in patients with high-risk.Methods: This is a case-control study. The single nucleotide polymorphism of -1562C>T allele of MMP9 gene promoter was genotyped by hit Tetra ARMS PCR technique in 100 diabetic patients with foot ulcer grade 1 or 2 as the case group according Wagne r classification and in 100 diabetic patients without foot ulcer as the control group.Results: The Chi-square test revealed significant difference in genotype frequency of CC, CT and TT alleles of -1562C>T allele of MMP9 gene promoter between case and control groups (P=0.000).Conclusion: According to this study, there is a relationship between -1562C>T allele of MMP9 gene promoter with DIABETIC FOOT ULCER in type2 diabetes patients. Thus we can introduce this BIOMARKER for evaluation of risk and prognosis of DIABETIC FOOT ULCERs.

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References

Nurses’ role in diabetic foot prevention and care; a review

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APA: Copy

SHAFIEE, SAHAR, RAZ, ABBASALI, ADIBI, NEDA, MANSOURI, MASOOMEH, ANNABESTANI, ZOHREH, MIRZAEEZADEH, ZAHRA, HASHEMI, MEHRDAD, & OMIDFAR, KOBRA. (2017). ASSESSMENT OF THE RELATIONSHIP BETWEEN -1562C>T ALLELE OF MMP9 GENE PROMOTER WITH DIABETIC FOOT ULCER IN TYPE 2 DIABETIC PATIENTS REFERRED TO THE CLINIC OF DIABETES AND METABOLIC DISEASES. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 17(1 ), 49-56. SID. https://sid.ir/paper/54041/en

Vancouver: Copy

SHAFIEE SAHAR, RAZ ABBASALI, ADIBI NEDA, MANSOURI MASOOMEH, ANNABESTANI ZOHREH, MIRZAEEZADEH ZAHRA, HASHEMI MEHRDAD, OMIDFAR KOBRA. ASSESSMENT OF THE RELATIONSHIP BETWEEN -1562C>T ALLELE OF MMP9 GENE PROMOTER WITH DIABETIC FOOT ULCER IN TYPE 2 DIABETIC PATIENTS REFERRED TO THE CLINIC OF DIABETES AND METABOLIC DISEASES. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2017;17(1 ):49-56. Available from: https://sid.ir/paper/54041/en

IEEE: Copy

SAHAR SHAFIEE, ABBASALI RAZ, NEDA ADIBI, MASOOMEH MANSOURI, ZOHREH ANNABESTANI, ZAHRA MIRZAEEZADEH, MEHRDAD HASHEMI, and KOBRA OMIDFAR, “ASSESSMENT OF THE RELATIONSHIP BETWEEN -1562C>T ALLELE OF MMP9 GENE PROMOTER WITH DIABETIC FOOT ULCER IN TYPE 2 DIABETIC PATIENTS REFERRED TO THE CLINIC OF DIABETES AND METABOLIC DISEASES,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 17, no. 1 , pp. 49–56, 2017, [Online]. Available: https://sid.ir/paper/54041/en

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