ANALYSIS OF ADIPONECTIN GENE POLYMORPHISM IN TYPE 2 DIABETIC PATIENTS IN A POPULATION FROM TEHRAN

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HASANI RANJ BAR SH.; TAVAKOLI BAZAZ J.; AMIRI P.; MOHAMMAD AMOLI M.; ARDESHIR LARIJANI MOHAMMAD BAGHER

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Journal: Iranian Journal of Diabetes and Metabolism Year:2007 | Volume:6 | Issue:3 Page(s): 215-218

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Title

ANALYSIS OF ADIPONECTIN GENE POLYMORPHISM IN TYPE 2 DIABETIC PATIENTS IN A POPULATION FROM TEHRAN

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Keywords

POLYMORPHISMQ2

ADIPONECTINQ2

DIABETES MELLITUSQ2

Abstract

Background: Single nucleotide POLYMORPHISMs of ADIPONECTIN gene have been associated with BMI, insulin sensitivity and type 2 diabetes, reportedly. In present study we performed a genetic association study for ADIPONECTIN gene at position +45*T/G in type 2 diabetes and normal subjects of Tehran population.Methods: Diabetic patients were selected from diabetes clinic and normal healthy control subjects aged between 25-64 years selected from zone 17 of Tehran. ADIPONECTIN gene POLYMORPHISM was analyzed using PCR-RFLP method in normal healthy controls (N=70), obese diabetic patients (N=80) and non-obese diabetic patients (N=72).Results: Frequency of TT genotype was 62.5% in non-obese diabetic patients and 78% in control group, that was statistically significant (TT vs TG+GG: P=0.02, OR=2.2, CI: 0.98-5.00). There was also a significant difference for allele T and G frequencies when we compared between non-obese diabetic patients and controls group. The frequency of allele G was increased in non-obese diabetic (20.1%) patients compared to controls (12%) (P: 0.04 OR: 1.8 CI: 0.9-3.7).Conclusion: This study showed TG and GG alleles of ADIPONECTIN gene POLYMORPHISM at position +45*T/G is risk factors for development of DIABETES MELLITUS while this effect is independent from BMI and obesity.

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APA: Copy

HASANI RANJ BAR, SH., TAVAKOLI BAZAZ, J., AMIRI, P., MOHAMMAD AMOLI, M., & ARDESHIR LARIJANI, MOHAMMAD BAGHER. (2007). ANALYSIS OF ADIPONECTIN GENE POLYMORPHISM IN TYPE 2 DIABETIC PATIENTS IN A POPULATION FROM TEHRAN. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 6(3), 215-218. SID. https://sid.ir/paper/54065/en

Vancouver: Copy

HASANI RANJ BAR SH., TAVAKOLI BAZAZ J., AMIRI P., MOHAMMAD AMOLI M., ARDESHIR LARIJANI MOHAMMAD BAGHER. ANALYSIS OF ADIPONECTIN GENE POLYMORPHISM IN TYPE 2 DIABETIC PATIENTS IN A POPULATION FROM TEHRAN. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2007;6(3):215-218. Available from: https://sid.ir/paper/54065/en

IEEE: Copy

SH. HASANI RANJ BAR, J. TAVAKOLI BAZAZ, P. AMIRI, M. MOHAMMAD AMOLI, and MOHAMMAD BAGHER ARDESHIR LARIJANI, “ANALYSIS OF ADIPONECTIN GENE POLYMORPHISM IN TYPE 2 DIABETIC PATIENTS IN A POPULATION FROM TEHRAN,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 6, no. 3, pp. 215–218, 2007, [Online]. Available: https://sid.ir/paper/54065/en

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