REDUCTION OF IN VIVO DEIODINATION OF RADIOIODINATED ANTIBODIES USING N-SUCCINIMIDYL-4-[125I] IODOBENZOATE

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BEYKI D.; SHAHHOSSEINI S.; KHALAJ A.; EFTEKHARI MEHRDAD; RAFIEE H.

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF NUCLEAR MEDICINE Year:2002 | Volume:- | Issue:18 Page(s): 21-26

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Title

REDUCTION OF IN VIVO DEIODINATION OF RADIOIODINATED ANTIBODIES USING N-SUCCINIMIDYL-4-[125I] IODOBENZOATE

Author(s)

Keywords

N-SUCCINIMIDYL-4-IODOBENZOATE

TURPENTINE

IN VIVO DEIODINATION

HUMAN NONSPECIFIC POLYCLONAL IGG

Abstract

Human nonspecific polyclonal IgG was labeled with125I through direct and indirect labeling methods using chloramines-T and a non-Phenolic radio iodinated intermediate N-Succinimidyl-4-[125I] iodobenzoate (125I-SIB), respectively. Tissue distribution of radio iodinated IgG was assessed in normal and induced inflammation mice. Although, radio iodinated IgG accumulated in the inflammatory area, results showed decreased thyroid and stomach activity and improved inflammatory thigh-to-normal tissue ratios with the indirect labeling method (125I-IB-IgG) compared with direct labeling method (125I-IgG), indicating reduced IN VIVO DEIODINATION. These results indicate that the 125I-SIB is probably a preferable approach for labeling antibodies with iodine radioisotopes.

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APA: Copy

BEYKI, D., SHAHHOSSEINI, S., KHALAJ, A., EFTEKHARI, MEHRDAD, & RAFIEE, H.. (2002). REDUCTION OF IN VIVO DEIODINATION OF RADIOIODINATED ANTIBODIES USING N-SUCCINIMIDYL-4-[125I] IODOBENZOATE. IRANIAN JOURNAL OF NUCLEAR MEDICINE, -(18), 21-26. SID. https://sid.ir/paper/542155/en

Vancouver: Copy

BEYKI D., SHAHHOSSEINI S., KHALAJ A., EFTEKHARI MEHRDAD, RAFIEE H.. REDUCTION OF IN VIVO DEIODINATION OF RADIOIODINATED ANTIBODIES USING N-SUCCINIMIDYL-4-[125I] IODOBENZOATE. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2002;-(18):21-26. Available from: https://sid.ir/paper/542155/en

IEEE: Copy

D. BEYKI, S. SHAHHOSSEINI, A. KHALAJ, MEHRDAD EFTEKHARI, and H. RAFIEE, “REDUCTION OF IN VIVO DEIODINATION OF RADIOIODINATED ANTIBODIES USING N-SUCCINIMIDYL-4-[125I] IODOBENZOATE,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. -, no. 18, pp. 21–26, 2002, [Online]. Available: https://sid.ir/paper/542155/en

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